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Fabrication and characterization of poly(DL-lactic-co-glycolic acid)/zirconia-hybridized amorphous calcium phosphate composites.
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Whited, Bryce M. Goldstein, Aaron S. Skrtic, Drago Love, Brian J. |
| Description | Country affiliation: United States Author Affiliation: Whited BM ( School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0298, USA.) |
| Abstract | Several minerals, such as hydroxyapatite and beta-tricalcium phosphate, have been incorporated into bioresorbable polyester bone scaffolds to increase the osteoconductivity both in vitro and in vivo. More soluble forms of calcium phosphate that release calcium and phosphate ions have been postulated as factors that increase osteoblast differentiation and mineralization. Recently, a zirconia-hybridized pyrophosphate-stabilized amorphous calcium phosphate (Zr-ACP) has been synthesized allowing controlled release of calcium and phosphate ions. When incorporated into bioresorbable scaffolds, Zr-ACP has the potential to induce osteoconductivity. In this study, 80-90% (w/v) porous poly(DL-lactic-co-glycolic acid) (PLGA) scaffolds were formed by thermal phase separation from dioxane while incorporating Zr-ACP. Scanning electron microscopy revealed a highly porous structure with a pore size ranging from a few microm to about 100 microm, smaller than we had hoped for. Zr-ACP particles were evenly dispersed in the composite structure and incorporated into the pore walls. The amorphous structure of the Zr-ACP was maintained during composite fabrication, as found by X-ray diffraction. Composite scaffolds had larger compressive yield strengths and moduli compared to pure polymer scaffolds. These initial efforts demonstrate that PLGA/Zr-ACP composites can be formed in ways that ultimately serve as promising bone scaffolds in tissue engineering. |
| File Format | HTM / HTML |
| ISSN | 09205063 |
| e-ISSN | 15685624 |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Issue Number | 4 |
| Volume Number | 17 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2006-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biomedical Engineering Bone Substitutes Chemical Synthesis Calcium Phosphates Chemistry Chlorides Lactic Acid Polyglycolic Acid Polymers Tissue Engineering Zirconium Compressive Strength Materials Testing Microscopy, Electron, Scanning Porosity Solvents X-ray Diffraction Comparative Study Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
