NDLI: Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation

Please wait, while we are loading the content...

Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation

High drug loading pH-sensitive pullulan-DOX conjugate nanoparticles for hepatic targeting.

Fast incorporation of primary amine group into polylactide surface for improving $C_{2}C_{12}$ cell proliferation using nitrogen-based atmospheric-pressure plasma jets

A comparative study of polyethylene glycol hydrogels derivatized with the RGD peptide and the cell-binding domain of fibronectin.

The effects of pore size in bilayered poly(lactide-co-glycolide) scaffolds on restoring osteochondral defects in rabbits.

Finite element analysis and cellular studies on advanced, controlled porous structures with subsurface continuity in bio-implantable titanium alloys.

Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response.

Year: 2013 Volume: 101

Year: 2012 Volume: 100

Year: 2011 Volume: 99

Year: 2011 Volume: 98

Year: 2011 Volume: 97

Year: 2011 Volume: 96

Year: 2010 Volume: 95

Year: 2010 Volume: 94

Year: 2010 Volume: 93

Year: 2010 Volume: 92

Year: 2009 Volume: 91

Year: 2009 Volume: 90

Year: 2009 Volume: 89

Year: 2009 Volume: 88

Year: 2008 Volume: 87

Year: 2008 Volume: 86

Year: 2008 Volume: 85

Year: 2008 Volume: 84

Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hoekstra, Jan Willem M. Van Den Beucken, Jeroen J. J. P. Leeuwenburgh, Sander C. G. Bronkhorst, Ewald M. Meijer, Gert J. Jansen, John A.
Description	Country affiliation: Netherlands Author Affiliation: Hoekstra JW ( Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands)
Abstract	Monitoring the degradation of calcium phosphate-based bone substitute materials in vivo by means of noninvasive techniques (e.g., radiography) is often a problem due to the chemical resemblance of those substitutes with the mineral phase of bone. In the view of that, the present study aimed at enhancing the radiopacity of calcium phosphate cement enriched with poly(lactic-co-glycolic acid) (CPC-PLGA) microspheres, by adding tantalum oxide $(Ta_{2}O_{5})$ or the more traditional radiopacifier barium sulfate $(BaSO_{4}).$ The radiopacifying capacity of these radiopacifiers was first evaluated in vitro by microcomputed tomography (μCT). Thereafter, both radiopacifiers were tested in vivo using a distal femoral condyle model in rabbits, with subsequent ex vivo μCT analysis in parallel with histomorphometry. Addition of either one of the radiopacifiers proved to enhance radiopacity of CPC-PLGA in vitro. The in vivo experiment showed that both radiopacifiers did not induce alterations in biological performance compared to plain CPC-PLGA, hence both radiopacifiers can be considered safe and biocompatible. The histomorphometrical assessment of cement degradation and bone formation showed similar values for the three experimental groups. Interestingly, μCT analysis showed that monitoring cement degradation becomes feasible upon incorporation of either type of radiopacifier, albeit that $BaSO_{4}$ showed more accuracy compared to $Ta_{2}O_{5}.$ © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 141–149, 2014.
File Format	HTM / HTML
ISSN	15493296
Issue Number	1
Volume Number	102
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rabbits Research Support, Non-u.s. Gov't Femur Lactic Acid Polyglycolic Acid Barium Sulfate Bone Substitutes Oxides Pharmacology Journal Article Discipline Biomedical Engineering Calcium Phosphates Tantalum Contrast Media Animals X-ray Microtomography
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Toward accelerated bone regeneration by altering poly(D,L-lactic-co-glycolic) acid porogen content in calcium phosphate cement.

In vitro degradation, biocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid)/calcium phosphate cement scaffold with unidirectional lamellar pore structure.

Incorporation of bioactive glass in calcium phosphate cement: material characterization and in vitro degradation.

Fabrication and characterization of poly(DL-lactic-co-glycolic acid)/zirconia-hybridized amorphous calcium phosphate composites.

The biological performance of injectable calcium phosphate/PLGA cement in osteoporotic rats.

In vitro and in vivo degradation of poly(D, L-lactide-co-glycolide)/amorphous calcium phosphate copolymer coated on metal stents.

Biodegradable internal fixation plates enabled with X-ray visibility by a radiopaque layer of ß-tricalcium phosphate and poly (lactic-co-glycolic acid).

Coating of ß-tricalcium phosphate scaffolds-a comparison between graphene oxide and poly-lactic-co-glycolic acid.

Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications.

Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation

Similar Documents

Toward accelerated bone regeneration by altering poly(D,L-lactic-co-glycolic) acid porogen content in calcium phosphate cement.

In vitro degradation, biocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid)/calcium phosphate cement scaffold with unidirectional lamellar pore structure.

Incorporation of bioactive glass in calcium phosphate cement: material characterization and in vitro degradation.

Fabrication and characterization of poly(DL-lactic-co-glycolic acid)/zirconia-hybridized amorphous calcium phosphate composites.

The biological performance of injectable calcium phosphate/PLGA cement in osteoporotic rats.

In vitro and in vivo degradation of poly(D, L-lactide-co-glycolide)/amorphous calcium phosphate copolymer coated on metal stents.

Biodegradable internal fixation plates enabled with X-ray visibility by a radiopaque layer of ß-tricalcium phosphate and poly (lactic-co-glycolic acid).

Coating of ß-tricalcium phosphate scaffolds-a comparison between graphene oxide and poly-lactic-co-glycolic acid.

Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications.

Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation