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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Priyadarshani, Priyanka Li, Yongchao Yang, ShangYou Yao, Li |
| Description | Author Affiliation: Priyadarshani P ( Department of Biological Sciences, Wichita State University, Fairmount 1845, Wichita, Kansas, 67260.); Li Y ( Department of Biological Sciences, Wichita State University, Fairmount 1845, Wichita, Kansas, 67260.); Yang S ( Department of Biological Sciences, Wichita State University, Fairmount 1845, Wichita, Kansas, 67260.); Yao L ( Department of Biological Sciences, Wichita State University, Fairmount 1845, Wichita, Kansas, 67260.) |
| Abstract | Degeneration of intervertebral discs (IVDs) results in an overall alteration of the biomechanics of the spinal column and becomes a major cause of low back pain. In this study, an injectable hydrogel composite is fabricated and characterized as a potential scaffold for the treatment of degenerated IVDs. Crosslinking of type II collagen-hyaluronic acid (HA) hydrogel with 1-ethyl-3(3-dimethyl aminopropyl) carbodiimide (EDC) increases the gel stability against collagenase digestion and reduces water uptake in comparison with non-crosslinked gel. Cell viability assay exhibits the proliferation of human nucleus pulposus (HNP) cells in hydrogels. The cells in non-crosslinked gel and the gel crosslinked with a low concentration of EDC (0.1 mM) show superior cell viability and morphology compared with cells in gels crosslinked with higher concentration of EDC. Quantitative PCR assay demonstrates the gene expression of extracellular matrix (ECM) by cells cultured in the gels. The expression of ECM genes by HNP cells in the gels demonstrated the phenotypic change of the cells. This study suggests that the type II collagen-HA hydrogel and crosslinked hydrogel (0.1 mM EDC) are permissive matrix for the growth of HNP cells and can be potentially applied in NP repair. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 2 |
| Volume Number | 104 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2016-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Collagen Type Ii Therapy Hyaluronic Acid Intervertebral Disc Hydrogels Cell Survival Humans Pharmacology Metabolism Drug Effects Journal Article Discipline Biomedical Engineering Pathology Chemistry Intervertebral Disc Degeneration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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