NDLI: Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cox, Sophie C. Jamshidi, Parastoo Grover, Liam M. Mallick, Kajal K.
Description	Country affiliation: United kingdom Author Affiliation: Cox SC ( Warwick Manufacturing Group, University of Warwick, Coventry CV4 7AL, UK.); Jamshidi P ( School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.); Grover LM ( School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.); Mallick KK ( Warwick Manufacturing Group, University of Warwick, Coventry CV4 7AL, UK. Electronic address: k.k.mallick@warwick.ac.uk.)
Abstract	Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20°C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture.
File Format	HTM / HTML
ISSN	09284931
Volume Number	35
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Durapatite Chemistry Magnesium Metal Nanoparticles Osteoblasts Physiology Strontium Zinc Apoptosis Biocompatible Materials Chemical Synthesis Cell Line Cell Proliferation Cell Survival Chemical Precipitation Humans Materials Testing Ultrastructure Cytology Particle Size Phase Transition Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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