NDLI: Glycosaminoglycan-targeted iron oxide nanoparticles for magnetic resonance imaging of liver carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Rui-Meng Fu, Chao-Ping Li, Nan-Nan Wang, Li Xu, Xiang-Dong Yang, Ding-Yan Fang, Jin-Zhi Jiang, Xin-Qing Zhang, Li-Ming
Description	Country affiliation: China Author Affiliation: Yang RM ( Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.); Fu CP ( DSAPM Lab and PCFM Lab, Institute of Polymer Science, Department of Polymer and Materials Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.); Li NN ( DSAPM Lab and PCFM Lab, Institute of Polymer Science, Department of Polymer and Materials Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.); Wang L ( Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.); Xu XD ( Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.); Yang DY ( DSAPM Lab and PCFM Lab, Institute of Polymer Science, Department of Polymer and Materials Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.); Fang JZ ( Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.); Jiang XQ ( Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China. Electronic address: jiangxinqing888@163.com.); Zhang LM ( DSAPM Lab and PCFM Lab, Institute of Polymer Science, Department of Polymer and Materials Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China)
Abstract	To develop an efficient probe for targeted magnetic resonance (MR) imaging of liver carcinoma, the surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) was carried out by conjugating a naturally-occurring glycosaminoglycan with specific biological recognition to human hepatocellular liver carcinoma (HepG2) cells. These modified SPIOs have good water dispersibility, superparamagnetic property, cytocompatibility and high magnetic relaxivity for MR imaging. When incubated with HepG2 cells, they demonstrated significant cellular uptake and specific accumulation, as confirmed by Prussian blue staining and confocal microscopy. The in vitro MR imaging of HepG2 cells and in vivo MR imaging of HepG2 tumors confirmed their effectiveness for targeted MR imaging of liver carcinoma.
File Format	HTM / HTML
ISSN	09284931
Volume Number	45
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Contrast Media Chemistry Ferric Compounds Glycosaminoglycans Magnetite Nanoparticles Amines Antigens, Cd44 Metabolism Carcinoma, Hepatocellular Pathology Cell Survival Drug Effects Hep G2 Cells Humans Hyaluronic Acid Liver Neoplasms Magnetic Resonance Imaging Toxicity Microscopy, Confocal Particle Size Radiography Spectroscopy, Fourier Transform Infrared Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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