NDLI: Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Zonggang Kang, Lingzhi Meng, Qing-Yuan Liu, Huanye Wang, Zhaoliang Guo, Zhongwu Cui, Fu-Zhai
Description	Author Affiliation: Chen Z ( National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China); Kang L ( National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China.); Meng QY ( Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, PR China.); Liu H ( Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110001, PR China.); Wang Z ( Jinan Military General Hospital of PLA, Jinan 250031, PR China.); Guo Z ( National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China. Electronic address: zwguo@sdu.edu.cn.); Cui FZ ( Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, PR China. Electronic address: cuifz@mail.tsinghua.edu.cn.)
Abstract	The nHAC/CSH composite is an injectable bone repair material with controllable injectability and self-setting properties prepared by introducing calcium sulfate hemihydrate (CSH) into mineralized collagen (nHAC). When mixed with water, the nHAC/CSH composites can be transformed into mineralized collagen/calcium sulfate dihydrate (nHAC/CSD) composites. The nHAC/CSD composites have good biocompatibility and osteogenic capability. Considering that the degradation behavior of bone repair material is another important factor for its clinical applications, the degradability of nHAC/CSD composites was studied. The results showed that the degradation ratio of the nHAC/CSD composites with lower nHAC content increased with the L/S ratio increase of injectable materials, but the variety of L/S ratio had no significant effect on the degradation ratio of the nHAC/CSD composites with higher nHAC content. Increasing nHAC content in the composites could slow down the degradation of nHAC/CSD composite. Setting accelerator had no significant effect on the degradability of nHAC/CSD composites. In vivo histological analysis suggests that the degradation rate of materials can match the growth rate of new mandibular bone tissues in the implanted site of rabbit. The regulable degradability of materials resulting from the special prescriptions of injectable nHAC/CSH composites will further improve the workability of nHAC/CSD composites.
File Format	HTM / HTML
ISSN	09284931
Volume Number	45
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Biocompatible Materials Metabolism Bone Substitutes Calcium Sulfate Chemistry Collagen Animals Pharmacology Bone Regeneration Drug Effects Humans Mandible Pathology Microscopy, Electron, Scanning Prostheses And Implants Rabbits Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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