NDLI: Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hu, Yang Wang, Jishuai Zhang, Hong Jiang, Guoqiang Kan, Chengyou
Description	Author Affiliation: Hu Y ( Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, PR China.); Wang J ( Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, PR China.); Zhang H ( Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, PR China.); Jiang G ( Department of Chemical Engineering, Key Laboratory of Industrial Biocatalysis of Ministry of Education, Tsinghua University, Beijing 100084, PR China. Electronic address: jianggq@mail.tsinghua.edu.cn.); Kan C ( Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, PR China. Electronic address: kancy@mail.tsinghua.edu.cn.)
Abstract	Monodispersed poly(styrene-co-N,N'-dimethylaminoethyl methacrylate) nanoparticles (P(St-co-DMAEMA) NPs) were synthesized by emulsion polymerization. Zeta potential, volume swelling ratio and in vitro release of fluorescer coumarin-6 from the NPs were determined in buffer of various pH. With an optimized formulation, the diameter of NPs is 100 nm approximately and the polydispersity index (PI) is less than 0.1. The NPs have a hydrophilic surface and alterable surface charge which is almost neutral at normal physiological pH, but becomes much more positive under acidic conditions. The volume swelling ratios and in vitro release of coumarin-6 are highly dependent on pH, which are significantly increased at the lower pH and higher DMAEMA/St molar ratio. More than 70% of the loaded coumarin-6 could be released in 24 h at pH2, which is 2.3-folds higher than that at normal physiological pH. The P(St-co-DMAEMA) NPs show promising applications to targeted drug delivery to tumors.
File Format	HTM / HTML
ISSN	09284931
Volume Number	45
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Drug Carriers Chemistry Nanoparticles Polymers Coumarins Metabolism Hydrogen-ion Concentration Methacrylates Microscopy, Electron, Transmission Particle Size Chemical Synthesis Polystyrenes Spectroscopy, Fourier Transform Infrared Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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