NDLI: Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morawska-Chochól, Anna Domalik-Pyzik, Patrycja Chlopek, Jan Szaraniec, Barbara Sterna, Jacek Rzewuska, Magdalena Bogun, Maciej Kucharski, Rafael Mielczarek, Przemyslaw
Description	Author Affiliation: Morawska-Chochól A ( AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland. Electronic address: morawska@agh.edu.pl.); Domalik-Pyzik P ( AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.); Chlopek J ( AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.); Szaraniec B ( AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.); Sterna J ( Warsaw University of Life Sciences - SGGW, Faculty of Veterinary Medicine, Department of Small Animal Diseases with Clinic, ul. Nowoursynowska 159c, 02-776 Warszawa, Poland.); Rzewuska M ( Warsaw University of Life Sciences - SGGW, Faculty of Veterinary Medicine, Department of Preclinical Sciences, ul. Ciszewskiego 8, 02-786 Warszawa, Poland.); Bogun M ( Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, ul. Zeromskiego 116, 90-924 Lodz, Poland.); Kucharski R ( CJS Sp. z o. o., Gen. Jankego 134/1, 40-617 Katowice, Poland); Mielczarek P ( AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biochemistry and Neurobiology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.)
Abstract	One of the major problems in orthopedic surgery is infection associated with implantation. The treatment is a very difficult and long-term process. A solution to this issue can be the use of implants which additionally constitute an antibiotic carrier preventing the development of an infection. Prototypes of biodegradable intramedullary nails made of three different composites with a poly(L-lactide) matrix were designed. The nails served as gentamicin sulfate (GS) carrier - an antibiotic commonly used in the treatment of osteomyelitis. The matrix was reinforced with carbon fibers (CF), alginate fibers (Alg) and magnesium alloy wires (Mg), as well as modified with bioactive particles of tricalcium phosphate (TCP) in various systems. In this way, novel, multi-phase and multifunctional degradable intramedullary nails were obtained. The tests demonstrated strong dependence between the type of the modifying phase introduced into the composite, and the rate of drug release. Introduction of gentamicin into the nail structure strengthened and prolonged antibacterial activity of the nails.
File Format	HTM / HTML
ISSN	09284931
Volume Number	45
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Anti-bacterial Agents Chemistry Biocompatible Materials Bone Nails Gentamicins Polyesters Alginates Alloys Administration & Dosage Pharmacology Microbiology Calcium Phosphates Glucuronic Acid Hexuronic Acids Humans Microscopy, Electron, Scanning Osteomyelitis Drug Therapy Prevention & Control Prostheses And Implants Staphylococcus Drug Effects Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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