NDLI: A novel thermal and pH responsive drug delivery system based on ZnO@PNIPAM hybrid nanoparticles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tan, Licheng Liu, Jian Zhou, Weihua Wei, Junchao Peng, Zhiping
Description	Country affiliation: China Author Affiliation: Tan L ( Department of Chemistry, Nanchang University, Nanchang 330031, China.); Liu J ( Department of Chemistry, Nanchang University, Nanchang 330031, China.); Zhou W ( Department of Chemistry, Nanchang University, Nanchang 330031, China.); Wei J ( Department of Chemistry, Nanchang University, Nanchang 330031, China); Peng Z ( Department of Chemistry, Nanchang University, Nanchang 330031, China.)
Abstract	A smart ZnO@PNIPAM hybrid was prepared by grafting thermal responsive poly(N-isopropylacrylamide) (PNIPAM) on zinc oxide (ZnO) nanoparticles via surface-initiated atom transfer radical polymerization (ATRP). The thermal gravimetric analysis (TGA) shows that the grafting amount of PNIPAM was about 38%, and the SEM images show that the PNIPAM chains can prevent the aggregation of ZnO nanoparticles. The responsive properties of ZnO@PNIPAM were measured by photoluminescence spectra, and the results demonstrate that the PNIPAM chains grafted on ZnO surfaces can realize reversible thermal responsive and photoluminescence properties. An anticancer drug, doxorubicin (Dox), was used as a model drug and loaded into the hybrid nanoparticles, and an in vitro drug release test implied that ZnO@PNIPAM could work as a thermal responsive drug delivery system. Furthermore, pH sensitive drug releases were carried out in acetate buffer at pH 5.0 and pH 6.0 and in water at pH7.0, and the results showed evident pH dependency, showing its pH responsive properties.
File Format	HTM / HTML
ISSN	09284931
Volume Number	45
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Acrylic Resins Chemistry Drug Carriers Nanoparticles Zinc Oxide Antibiotics, Antineoplastic Metabolism Doxorubicin Chemical Synthesis Drug Liberation Hydrodynamics Hydrogen-ion Concentration Ultrastructure Temperature Thermogravimetry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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