NDLI: Preliminary investigation of a novel technique for the quantification of the ex vivo biomechanical properties of the vocal folds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Coelho, Paulo G. Sobieraj, Michael Tovar, Nick Andrews, Kenneth Paul, Benjamin Govil, Nandini Jeswani, Seema Amin, Milan R. Janal, Malvin N. Branski, Ryan C.
Description	Author Affiliation: Coelho PG ( Biomaterials and Biomimetics, College of Dentistry, New York University, New York, NY, USA. Electronic address: pc92@nyu.edu.); Sobieraj M ( Orthopedic Surgery, Hospital for Joint Diseases, New York University, New York, NY, USA.); Tovar N ( Biomaterials and Biomimetics, College of Dentistry, New York University, New York, NY, USA.); Andrews K ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.); Paul B ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.); Govil N ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.); Jeswani S ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.); Amin MR ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.); Janal MN ( Departments of Public Health and Epidemiology, New York University, New York, NY, USA.); Branski RC ( NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.)
Abstract	The human vocal fold is a complex structure made up of distinct layers that vary in cellular and extracellular matrix composition. Elucidating the mechanical properties of vocal fold tissues is critical for the study of both acoustics and biomechanics of voice production, and essential in the context of vocal fold injury and repair. Both quasistatic and dynamic behavior in the 10-300 Hz range was explored in this preliminary investigation. The resultant properties of the lamina propria were compared to that of the nearby thyroarytenoid muscle. Er, quantified via quasistatic testing of the lamina propria, was 609±138 MPa and 758±142 MPa in the muscle (p=0.001). E' of the lamina propria as determined by dynamic testing was 790±526 MPa compared to 1061±928 MPa in the muscle. Differences in E' did not achieve statistical significance via linear mixed effect modeling between the tissue types (p=0.95). In addition, frequency dependence was not significant (p=0.18).
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	45
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Vocal Cords Physiology Animals Biomechanical Phenomena Mucous Membrane Muscles Rabbits Wound Healing Journal Article
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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