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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xing, Houjuan Wang, Zhilei Wu, Hongda Zhao, Xia Liu, Tao Li, Shu Xu, Shiwen |
| Description | Author Affiliation: Xing H ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China); Wang Z ( Animal Health Supervision Institute of Heilongjiang Province, 243 Haping Road, Xiangfang District, Harbin 150069, PR China.); Wu H ( Institute of Animal Science, Academy of Agricultural Sciences of Heilongjiang Province, 368 Xuefu Road, Xiangfang District, Harbin 150086, PR China.); Zhao X ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China.); Liu T ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China.); Li S ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China.); Xu S ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China. Electronic address: shiwenxu@neau.edu.cn.) |
| Abstract | This study assessed the impacts of atrazine (ATR), chlorpyrifos (CPF) and combined ATR/CPF exposure on the kidney of common carp (Cyprinus carpio L.). The carp were sampled after a 40-d exposure to CPF and ATR, individually or in combination, followed by a 40-d recovery to measure the expression levels of heat shock proteins genes (HSP60, HSP70 and HSP90) and pesticide residues in the kidney tissue. The results revealed that the mRNA and protein levels of HSP60, HSP70 and HSP90 were induced in the kidney of common carp by ATR, CPF, and ATR/CPF mixture. The accumulated amounts of ATR, CPF, and their metabolites in the kidney tissues exhibited dose-dependency. These results exhibited that increasing concentration of ATR and CPF in the environment causes considerable stress for common carp, suggesting that the expression levels of HSP60, HSP70 and HSP90 may act as potential biomarkers for assessing the environmental ATR and CPF risk for carp. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Volume Number | 113 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Atrazine Toxicity Chlorpyrifos Heat-shock Proteins Metabolism Kidney Drug Effects Pesticide Residues Animals Blotting, Western Carps Gene Expression Hsp70 Heat-shock Proteins Rna, Messenger Real-time Polymerase Chain Reaction Risk Assessment Water Pollutants, Chemical Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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