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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xing, Houjuan Wang, Zhilei Gao, Xuejiao Chen, Dechun Wang, Liangliang Li, Shu Xu, Shiwen |
| Description | Author Affiliation: Xing H ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China); Wang Z ( Animal Health Supervision Institute of Heilongjiang Province, 243 Haping Road, Xiangfang District, Harbin 150069, PR China.); Gao X ( College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130032, PR China.); Chen D ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China.); Wang L ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China.); Li S ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China. Electronic address: lishu@neau.edu.cn.); Xu S ( College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin 150030, PR China. Electronic address: shiwenxu@neau.edu.cn.) |
| Abstract | Under normal conditions, autophagy occurs at basal levels but can be induced rapidly in response to stress conditions and extracellular signals. Increasing experimental evidence indicates that the expression of autophagy-related genes play very important roles in toxicology. Atrazine (ATR) and chlorpyrifos (CPF) are the most common agrochemical in the freshwater ecosystems of the world. This study assessed the effects of ATR, CPF and combined ATR/CPF exposure on the liver of common carp. Carp were sampled after a 40-d exposure to ATR and CPF, individually or in combination, followed by a 40-d recovery to measure the mRNA and protein levels of autophagy-related genes in the liver. In addition, we also investigated the change in ultrastructure in the liver. The results revealed that the mRNA and protein levels of microtubule-associated protein 1 light chain 3 B (LC3B) and dynein were significantly induced in the treated groups compared to the solvent control group. Transmission electron microscope assays indicated that autolysosomes were observed in the exposure and recovery groups. These results indicated that ATR and CPF could induce autophagy in carp liver. To the best of our knowledge, this is the first report to study the autophagy effects caused by sub-chronic exposure to ATR, CPF and the ATR/CPF combination in common carp. The information presented in the present study may provide new insights into the mechanisms used by fish to adapt to stressful environments. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Volume Number | 113 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Atrazine Toxicity Autophagy Carps Chlorpyrifos Herbicides Insecticides Water Pollutants, Chemical Animals Metabolism Dyneins Genetics Liver Drug Effects Ultrastructure Microtubule-associated Proteins Rna, Messenger Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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