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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Magdaleno, A. Saenz, M. E. Juárez, A. B. Moretton, J. |
| Description | Author Affiliation: Magdaleno A ( Cátedra de Higiene y Sanidad, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 4° Piso, C1113AAC Buenos Aires, Argentina. Electronic address: amagda@ffyb.uba.ar.); Saenz ME ( Cátedra de Higiene y Sanidad, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 4° Piso, C1113AAC Buenos Aires, Argentina.); Juárez AB ( Departamento de Biodiversidad y Biología Experimental y Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina); Moretton J ( Cátedra de Higiene y Sanidad, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 4° Piso, C1113AAC Buenos Aires, Argentina.) |
| Abstract | The effect of ampicillin (AMP), amoxicillin (AMX), cephalotin (CEP), ciprofloxacin (CPF), gentamycin (GEN), and vancomycin (VAN) have been examined individually and as binary mixtures, on a non-target aquatic organism, the green alga Pseudokichneriella subcapitata. The ß-lactam antibiotics AMP and AMX were not toxic to the alga at concentrations up to 2000 mgl(-1) (less than 10% of algal growth inhibition), whereas the fluoroquinolone CPF, and the aminoglycoside GEN were the most toxic antibiotics, with an EC50=11.3 ± 0.7 mgl(-1) and 19.2 ± 0.5 mgl(-1), respectively. The cephalosporin CEP and the glycopeptide VAN were less toxic than the last two mentioned, showing an EC50>600 mgl(-1) and 724 ± 20 mgl(-1), respectively. The toxicological interactions of binary mixtures were predicted by the two classical models of additivity: concentration addition (CA) and independent action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 1 and 50 mgl(-1). In all cases a clear synergistic effect was observed, showing that single compound toxicity data are not adequate for the prediction of aquatic toxicities of antibiotic mixtures. Risk assessment was performed by calculating the ratio between predicted environmental concentrations (PEC) and the predicted no effect concentration (PNEC). All the antibiotics tested, excepting GEN, have a potential ecological risk, taking into account the PEC of hospital effluents from Buenos Aires, Argentina. These risks increase when antibiotics are present in binary mixtures. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Journal | Ecotoxicology and Environmental Safety |
| Volume Number | 113 |
| e-ISSN | 10902414 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Anti-bacterial Agents Toxicity Chlorophyta Drug Effects Growth & Development Drug Interactions Risk Assessment Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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