NDLI: The role of novel biomarker HE4 in endometrial cancer: a case control prospective study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Angioli, Roberto Plotti, Francesco Capriglione, Stella Montera, Roberto Damiani, Patrizio Ricciardi, Roberto Aloisi, Alessia Luvero, Daniela Cafà, Ester Valentina Dugo, Nella Angelucci, Michela Benedetti-Panici, Pierluigi
Description	Country affiliation: Italy Author Affiliation: Angioli R ( Department of Obstetrics and Gynaecology, Campus Bio-Medico University of Rome, Via Alvaro del Portillo, 200-00128, Rome, Italy.)
Abstract	The aim of the study was to explore the clinical value of serum human epididymis secretory protein E4 (HE4) and CA125 in endometrial carcinoma. From January 2010 to April 2012, serum specimens were collected from consecutive cases of endometrial carcinoma and from cases of uterus benign disease (control group). The CA125 normal value is considered less than 35 U/mL. Two HE4 cutoff are considered: less than 70 pmol/L and less than 150 pmol/L. The specificity analysis was performed using the Mann-Whitney test for the CA125 and HE4 series. The level of statistical significance is set at p < 0.05. The sensitivity of CA125 in detecting endometrial cancer is 19.8 %, whereas the sensitivity of HE4 is 59.4 and 35.6 % for 70 and 150 pmol/L cutoff, respectively. Thus the specificity of HE4 is 100 % (positive predictive value = 100 %, negative predictive value = 71.52 and 61.31 % considering the two HE4 cutoff, respectively), whereas the CA125 specificity is 62.14 % (positive predictive value = 33.9 %, negative predictive value = 44.14 %) in detection of endometrial cancer. Combining CA125 and HE4, the sensitivity to detect endometrial cancer is 60.4 and 34.6 %, at HE4 cutoff of 70 and 150 pmol/L, respectively, with a specificity of 100 %. HE4 may be a new tool for preoperative evaluation and postoperative surveillance of endometrial cancer patients, with a positive predictive value = 100 %. HE4 at cutoff of 70 pmol/L yields the best sensitivity and specificity.
File Format	HTM / HTML
ISSN	10104283
Issue Number	1
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Ca-125 Antigen Blood Endometrial Neoplasms Diagnosis Membrane Proteins Proteins Analysis Adult Aged Aged, 80 And Over Tumor Markers, Biological Case-control Studies Metabolism Epididymal Secretory Proteins Female Humans Lymph Nodes Pathology Middle Aged Prospective Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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