NDLI: The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oliveira-Neto, Helenisa Helena de Souza, Pedro Paulo Chaves da Silva, Márcio Roberto Barbosa Mendonça, Elismauro Francisco Silva, Tarcília Aparecida Batista, Aline Carvalho
Description	Country affiliation: Brazil Author Affiliation: Oliveira-Neto HH ( Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, CEP 74605-220, Brazil.)
Abstract	The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19(+) and CCL21(+) cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	1
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Carcinoma, Squamous Cell Metabolism Secondary Chemokine Ccl19 Chemokine Ccl21 Mouth Neoplasms Receptors, Ccr7 Genetics Female Humans Lymph Nodes Pathology Lymphatic Metastasis Male Middle Aged Rna, Messenger Treatment Outcome Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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