NDLI: Heterozygosity for TGF ß1 -509C/T Polymorphism is associated with risk for breast cancer in South Indian population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vinod, Cingeetham Jyothy, A. Vijay Kumar, M. Raghu Raman, R. Nallari, Pratibha Venkateshwari, A.
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Vinod C ( Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, India.)
Abstract	Transformation growth factor ß1 is a multipotent cytokine that mediates the development, differentiation, and neoplasm of the mammary gland. TGF ß1 is known to exert both tumor suppressive and progressive effect at different stages of carcinogenesis. Several studies have shown the association of TGF ß1 expression with breast cancer markers like estrogen receptor (ER), progesterone receptor (PR), and Her2/neu. TGF ß1 expression is known to be influenced by -509C/T promoter polymorphism. Hence, the present study is aimed to evaluate the possible role of TGF ß1 -509C/T promoter polymorphism in breast cancer and its association with ER, PR, and Her2 status based on case-control study in South Indian population from Andhra Pradesh. Our study revealed a significant increase of CT genotype in breast cancer patients compared to controls (CT vs. CC: χ (2) = 6.054, P = 0.014, OR 2.005, 95 % CI 1.182-3.403). However, there was no correlation between TGF ß1 -509C/T polymorphism and other factors like age at onset, ER, PR, Her2 status, etc. Further, CT genotype was found to be associated with increased risk in advanced stages of breast cancer (CC vs. CT: OR 2.315, 95 % CI 1.143-4.688) and a border line significance with postmenopausal women (CT vs. CC: χ (2) = 3.128, P = 0.07, OR 2.095, 95 % CI 0.991-4.428).
File Format	HTM / HTML
ISSN	10104283
Issue Number	1
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Breast Neoplasms Genetics Heterozygote Transforming Growth Factor Beta1 Metabolism Case-control Studies Female Genetic Predisposition To Disease Genotype Humans India Polymorphism, Single Nucleotide Postmenopause Promoter Regions, Genetic Receptor, Erbb-2 Receptors, Estrogen Receptors, Progesterone Risk Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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