NDLI: Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Erkutlu, Ibrahim Cigiloglu, Ahmet Kalender, Mehmet Emin Alptekin, Mehmet Demiryurek, A. Tuncay Suner, Ali Ozkaya, Esma Ulasli, Mustafa Camci, Celalettin
Description	Country affiliation: Turkey Author Affiliation: Erkutlu I ( Department of Neurosurgery, School of Medicine, Gaziantep University, 27310, Gaziantep, Turkey.)
Abstract	Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment.
File Format	HTM / HTML
ISSN	10104283
Issue Number	2
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Tumor Markers, Biological Genetics Brain Neoplasms Brain Metabolism Glioblastoma Signal Transduction Rho-associated Kinases Pathology Case-control Studies Cofilin 1 Cofilin 2 Female Humans Lim Kinases Male Middle Aged Mitogen-activated Protein Kinase 1 Prognosis Proto-oncogene Proteins C-bcl-2 Rna, Messenger Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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