NDLI: Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tassidis, Helena Brokken, Leon J. S. Jirström, Karin Bjartell, Anders Ulmert, David Härkönen, Pirkko Wingren, Anette Gjörloff
Description	Country affiliation: Sweden Author Affiliation: Tassidis H ( Department of Laboratory Medicine, Division of Tumor Biology, Lund University, Lund, Sweden.)
Abstract	Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression.
File Format	HTM / HTML
ISSN	10104283
Issue Number	2
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Cytoplasm Metabolism Prostatic Neoplasms Mortality Protein Tyrosine Phosphatase, Non-receptor Type 11 Aged Disease Progression Follow-up Studies Humans Immunoenzyme Techniques Male Middle Aged Neoplasm Staging Phosphorylation Prognosis Prostatectomy Pathology Signal Transduction Stromal Cells Survival Rate Tissue Array Analysis Tumor Cells, Cultured Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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