NDLI: Overexpression of KPNA2 correlates with poor prognosis in patients with gastric adenocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Chen Ji, Lv Ding, Zhong-Yang Zhang, Qian-De Huang, Guo-Rong
Description	Country affiliation: China Author Affiliation: Li C ( Department of Gastroenterology, Xuzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No.169, Zhongshan South Road, Xuzhou, 221000, China.)
Abstract	This study aims to investigate the expression and significance of KPNA2 in human gastric adenocarcinoma progression and prognosis. Using immunohistochemistry and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of KPNA2 in gastric adenocarcinoma tissues compared to paired normal stomach mucosa tissues in 30 patients (p < 0.05). In order to investigate the correlations between KPNA2 and the clinicopathological features of gastric adenocarcinoma, the expression of KPNA2 in 142 patients with gastric adenocarcinoma was detected by immunohistochemistry, and the results showed that overexpression of KPNA2 was associated with the size of tumor (p < 0.001), histological grade (p < 0.001), lymph node involvement (p = 0.001), and tumor node metastasis stage (p < 0.001). Kaplan-Meier survival analysis showed that patients with high KPNA2 expression showed a significantly shorter overall survival time compared with patients with low KPNA2 expression. Multivariate analysis suggested that KPNA2 expression might be an independent prognostic indicator (p < 0.001) for the survival of patients with gastric adenocarcinoma. In conclusion, overexpression of KPNA2 is closely related to progression of gastric adenocarcinoma and might be regarded as an independent predictor of poor prognosis for gastric adenocarcinoma.
File Format	HTM / HTML
ISSN	10104283
Issue Number	2
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Adenocarcinoma, Mucinous Mortality Adenocarcinoma Carcinoma, Papillary Carcinoma, Signet Ring Cell Stomach Neoplasms Alpha Karyopherins Metabolism Pathology Adult Aged Case-control Studies Female Follow-up Studies Humans Immunoenzyme Techniques Lymph Nodes Lymphatic Metastasis Male Middle Aged Neoplasm Staging Prognosis Rna, Messenger Genetics Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Survival Rate Young Adult Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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