NDLI: Loss of MUC2 expression predicts disease recurrence and poor outcome in colorectal carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elzagheid, Adam Emaetig, Fatma Buhmeida, Abdelbaset Laato, Matti El-Faitori, Omran Syrjänen, Kari Collan, Yrjö Pyrhönen, Seppo
Description	Country affiliation: Libya Author Affiliation: Elzagheid A ( Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya. elzagheid@yahoo.com)
Abstract	Clinical staging and histological grading after surgery have been the 'gold standard' for predicting prognosis and planning for adjuvant therapy of colorectal cancer (CRC). With the recent development of molecular markers, it has become possible to characterize tumors at the molecular level. This is important for stage II and III CRCs, in which clinicopathological features do not accurately predict heterogeneity, e.g., in their tumor response to adjuvant therapy. In the present study, archival samples from 141 patients with stage I, II, III, or IV CRC treated during 1981-1990 at Turku University Hospital (Finland) were used (as microarray blocks) to analyze MUC2 expression by immunohistochemistry. Altogether, 49.7 % of all tumors were positive for MUC2. There was no significant correlation between MUC2 expression and age (P < 0.499), tumor invasion (P < 0.127), tumor staging (P < 0.470), histological grade (P < 0.706), lymph node involvement (P < 0.854), or tumor metastasis (P < 0.586). However, loss of MUC2 expression was significantly associated with disease recurrence (P < 0.031), tumor localization (P < 0.048), and with borderline significance with gender (P < 0.085). In univariate (Kaplan-Meier) survival analysis, positive MUC2 significantly predicted longer disease-free survival (DFS) and disease-specific survival (DSS) as well. However, in multivariate (Cox) survival analysis, MUC2 lost its power as an independent predictor of DFS and DSS. Our results implicate the value of MUC2 expression in predicting disease recurrence and long-term survival in CRC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	2
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Adenocarcinoma Mortality Colorectal Neoplasms Mucin-2 Metabolism Neoplasm Recurrence, Local Secondary Aged Pathology Female Follow-up Studies Humans Immunoenzyme Techniques Lymphatic Metastasis Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Survival Rate Tissue Array Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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