NDLI: Overexpression of MAC30 is associated with poor clinical outcome in human non-small-cell lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Han, Kai-Yu Gu, Xin Wang, Hao-Ran Liu, Dong Lv, Fu-Zhen Li, Jia-Ning
Description	Country affiliation: China Author Affiliation: Han KY ( Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, No. 148, Baojian Rd, Nangang District, Harbin, 150086, Heilongjiang Province, China.)
Abstract	The aim of this study was to detect MAC30 expression in human non-small cell lung cancer (NSCLC) and to analyze its association with prognosis of NSCLC patients. Quantitative real-time RT-PCR was performed to examine the expression of MAC30 mRNA in 20 cases of NSCLC and corresponding non-tumor tissue samples. Immunohistochemistry was performed to detect the expression of MAC30 in 95 NSCLC tissues. We found that the expression levels of MAC30 mRNA in NSCLC tissues were significantly higher than those in corresponding non-tumor tissues. High-level MAC30 expression was correlated with poor tumor differentiation, TNM stage, and lymph node metastasis. Patients with high expression levels of MAC30 showed lower overall survival rate than those with low expression levels. Multivariate analysis showed that high MAC30 protein expression was an independent prognostic factor for NSCLC patients. Our study suggests that over-expression of MAC30 may play an important role in the progression of NSCLC and MAC30 expression may offer a valuable marker for predicting the outcome of patients with NSCLC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	2
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Adenocarcinoma Mortality Tumor Markers, Biological Metabolism Carcinoma, Non-small-cell Lung Carcinoma, Squamous Cell Lung Neoplasms Membrane Proteins Pathology Adult Aged Aged, 80 And Over Genetics Disease Progression Female Follow-up Studies Humans Immunoenzyme Techniques Lymphatic Metastasis Male Middle Aged Neoplasm Staging Prognosis Rna, Messenger Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Survival Rate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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