NDLI: Abnormality of Wnt3a expression as novel specific biomarker for diagnosis and differentiation of hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pan, Liuhong Yao, Min Zheng, Wenjie Gu, Juanjuan Yang, Xuli Qiu, Liwei Cai, Yin Wu, Wei Yao, Dengfu
Description	Country affiliation: China Author Affiliation: Pan L ( Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu, 226001, China.); Yao M ( Department of Immunology, Medical School of Nantong University, Nantong, Jiangsu, 226001, China.); Zheng W ( Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu, 226001, China.); Gu J ( Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.); Yang X ( Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.); Qiu L ( Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu, 226001, China.); Cai Y ( Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.); Wu W ( Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu, 226001, China.); Yao D ( Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu, 226001, China. yaodf@ahnmc.com.)
Abstract	The member 3a of Wingless-type MMTV integration site family (Wnt3a) as an oncogene is overexpressed in many kinds of tumors with a worse outcome. However, the mechanism and alteration of Wnt3a expression in hepatocellular carcinoma (HCC) have not been clarified. In this study, the levels of Wnt3a expression were investigated in 80 HCC tissues or sera of 186 patients with chronic liver diseases. The incidence of hepatic Wnt3a expression in HCC tissues was 96.25 % and significantly higher (χ (2) = 48.818, P < 0.001) than that in their surrounding tissues (46.25 %). The higher level (>800 ng/L) of circulating Wnt3a expression was found in 92.5 % HCC patients and significantly related (P < 0.05) to alpha-fetoprotein (AFP) level, liver cirrhosis, hepatitis B virus infection, poor differentiation, tumor node metastasis, and extra-hepatic metastasis. The level of Wnt3a expression in HCC patients was obviously higher (P < 0.001) than that in any group of cases with benign liver diseases. The diagnostic specificity or the area under the receiver operating characteristic curve was 94.34 % or 0.994 in Wnt3a and 69.81 % or 0.710 in AFP for HCC, respectively. The present data suggested that Wnt3a expression associated with tumor progression should be a novel specific biomarker for diagnosis and differentiation of HCC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	4
Journal	Tumor Biology
Volume Number	37
e-ISSN	14230380
Language	English
Publisher	Springer
Publisher Date	2016-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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