NDLI: Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hamadien, Maha-Abdulla Khan, Zahid Vaali-Mohammed, Mansoor-Ali Zubaidi, Ahmad Al-Khayal, Khayal McKerrow, James Al-Obeed, Omar
Description	Country affiliation: Saudi Arabia Author Affiliation: Hamadien MA ( Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 7805 (37), Riyadh, 11472, Saudi Arabia. mabdulla@ksu.edu.sa.); Khan Z ( Genomic Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.); Vaali-Mohammed MA ( Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 7805 (37), Riyadh, 11472, Saudi Arabia.); Zubaidi A ( Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 7805 (37), Riyadh, 11472, Saudi Arabia.); Al-Khayal K ( Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 7805 (37), Riyadh, 11472, Saudi Arabia.); McKerrow J ( Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, La Jolla, CA, USA.); Al-Obeed O ( Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 7805 (37), Riyadh, 11472, Saudi Arabia.)
Abstract	Tumor necrosis factor-alpha (TNF- ) contributes in inflammation and has been implicated in the development of colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) in TNF- promoter could affect the risk of CRC by regulating TNF- production. This is the first study to investigate TNF- SNPs in a Middle Eastern population. In this study, we examined three SNPs in TNF- for association with CRC. One hundred CRC patients and 100 controls were genotyped for TNF- -308, -238, and -857 using TaqMan allelic discrimination assay. The TNF- -238 (G/A) genotype was significantly associated with high risk of CRC (p = 0.003552). The distribution of three genotypes of -238 G/A was significantly different between the controls and CRC patients even after Bonferroni's correction. The AA genotype of -238 G/A SNP was observed at considerably higher proportion (13 %) in CRCs compared to controls (1 %). Additionally, similar to genotypes, the allelic frequencies of -238 G/A were significantly different between the CRC cases and controls (odds ratios (OR) = 7.647, χ (2) = 18.50, p = 0.00002). The genotype frequencies of -308 and -857 were not notably different between the cases and controls. TNF- -238A may be useful as a screening marker to identify individuals prior to their acquiring CRC in the Saudi population although, further validations in larger cohorts are needed.
File Format	HTM / HTML
ISSN	10104283
e-ISSN	14230380
DOI	10.1007/s13277-015-4421-z
Journal	Tumor Biology
Issue Number	4
Volume Number	37
Language	English
Publisher	Springer
Publisher Date	2016-04-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Tumour Cancer Oncology
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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