NDLI: Identification of phosphatidylcholine and lysophosphatidylcholine as novel biomarkers for cervical cancers in a prospective cohort study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yin, Ming-Zhu Tan, Shu Li, Xia Hou, Yan Cao, Guosheng Li, Kang Kou, Junping Lou, Ge
Description	Author Affiliation: Yin MZ ( State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, People's Republic of China.); Tan S ( Department of Pathology, Yale School of Medicine, New Haven, USA.); Li X ( Department of Gynecology Oncology, The Tumor Affiliated Hospital of Harbin Medical University, Harbin, 150086, People's Republic of China.); Hou Y ( Department of Pathology, Yale School of Medicine, New Haven, USA.); Cao G ( Department of Pathology, Yale School of Medicine, New Haven, USA.); Li K ( Department of Epidemiology and Biostatistics, Harbin Medical University, Harbin, 150081, People's Republic of China.); Kou J ( State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, People's Republic of China.); Lou G ( Department of Epidemiology and Biostatistics, Harbin Medical University, Harbin, 150081, People's Republic of China. likang@ems.hrbmu.edu.cn.)
Abstract	Metabolites are the end products of cellular regulatory processes. Squamous cervical cancer (SCC) can alter the level of certain small molecular metabolite in plasma through modulating gene expression. In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). In external prospective cohort, our assay has a sensitivity of 93.2 %, a specificity of 91.3 %, and an area under the receiver operating characteristic (ROC) curve (AUC) of 0.972. The level of LPC is significantly higher in SCC than in UF patients. An opposite result was observed in PC level. Our findings suggest that the PC and lysoPC could be used as novel biomarkers to facilitate SCC diagnosis.
File Format	HTM / HTML
ISSN	10104283
Issue Number	4
Journal	Tumor Biology
Volume Number	37
e-ISSN	14230380
Language	English
Publisher	Springer
Publisher Date	2016-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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