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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Antu, Kalathookunnel Antony Riya, Mariam Philip Nair, Anupama Mishra, Arvind Srivastava, Arvind K. Raghu, Kozhiparambil Gopalan |
| Description | Country affiliation: India Author Affiliation: Antu KA ( Agroprocessing and Natural Products Division, CSIR - National Institute for Interdisciplinary Science and Technology(NIIST), Thiruvananthapuram 695019, Kerala, India.); Riya MP ( Agroprocessing and Natural Products Division, CSIR - National Institute for Interdisciplinary Science and Technology(NIIST), Thiruvananthapuram 695019, Kerala, India.); Nair A ( Agroprocessing and Natural Products Division, CSIR - National Institute for Interdisciplinary Science and Technology(NIIST), Thiruvananthapuram 695019, Kerala, India.); Mishra A ( Division of Biochemistry, CSIR - Central Drug Research Institute(CDRI), Sector 10, Janakipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India.); Srivastava AK ( Division of Biochemistry, CSIR - Central Drug Research Institute(CDRI), Sector 10, Janakipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India.); Raghu KG ( Agroprocessing and Natural Products Division, CSIR - National Institute for Interdisciplinary Science and Technology(NIIST), Thiruvananthapuram 695019, Kerala, India. Electronic address: raghukgopal@niist.res.in.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: This plant has been utilized in Indian system of medicine for treatment of diabetes. This is clearly evident from the composition of Ayurvedic preparation for diabetes 'Nisakathakadi Kashayam' where this is one of the main ingredients of this preparation AIM OF THE STUDY: The study aims in elucidating the molecular mechanisms underlying the insulin sensitizing effects of Symplocos cochinchinensis ethanol extract (SCE) using a high fructose and saturated fat (HFS) fed insulin resistant rat model. MATERIALS AND METHODS: Experimental groups consisted of normal diet (ND), ND+SCE 500mg/kg bwd, HFS+vehicle, HFS+metformin 100mg/kg bwd, HFS+SCE 250/500mg/kg bwd. Initially the animals were kept under HFS diet for 8 weeks, and at the end of 8 week period, animals were found to develop insulin resistance and dyslipidemia. Post-administration of SCE, metformin or vehicle were carried out for 3 weeks. Gene and protein expressions relevant to insulin signalling pathway were analysed. RESULTS: HFS significantly altered the normal physiology of animals via proteins and genes relevant to metabolism like stearoyl-CoA desaturase (SCD1), sterol regulatory element binding protein 1 (SREBP-1c), fatty acid synthase (FAS), glucose 6 phosphatase (G6Pase), phosphoenol pyruvate carboxykinase (PEPCK), glucose transporter 2 (GLUT2), protein tyrosine phosphatse 1B (PTP1B), peroxisome proliferator activated receptor alpha (PPAR alpha), sirtuin 1 (SIRT1) and glucokinase. SCE administration attenuates the insulin resistance in HFS rat by the down regulation of SCD1 gene expression that modulates SREBP-1c dependent and independent hepatic lipid accumulation. CONCLUSION: SCE enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in HFS rat model. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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