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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Gao-Ge Shih, Jui-Hu Chiou, Shih-Hwa Hong, Chen-Jee Lu, Shao-Wei Pao, Li-Heng |
| Description | Country affiliation: China Author Affiliation: Sun GG ( School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China.); Shih JH ( Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.); Chiou SH ( Institute of Pharmacology, National Yang-Ming University & Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.); Hong CJ ( Department of Psychiatry, Taipei Veterans General Hospital & School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.); Lu SW ( Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.); Pao LH ( School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: An efficacious antidepressant without unwanted side effects is need urgently at present. This study aimed to investigate whether treatment with four Chinese herbal medicines (CHMs), namely Radix Astragali, Saposhnikovia divaricate (SD), Eucommia ulmoides Oliv. bark (EU), and Corydalis yanhusuo W. T. Wang (C. yanhusuo), could reverse the effects of chronic mild stress (CMS) in a depression-like mouse model and the potential mechanism(s) of their action. MATERIALS AND METHODS: In vitro study, the proliferation of NSCs was assessed using the MTS assay. In vivo study, chronic mild stress (CMS) was used in mice for 14 days to establish a depression-like mouse model. Plasma corticosterone levels were assessed by UPLC coupled to a triple-quadrupole mass spectrometer. The forced swim test (FST) was used to assess the effects of the four CHMs on depression. BrdU incorporation and TUNEL staining were used to assay hippocampal precursor cell proliferation rate and apoptosis. RESULTS: The CHMs included Radix Astragali, EU, C. yanhusuo, and SD were shown to promote neuroproliferation in vitro. In vivo study, oral administration of these four CHMs for 14 days reversed the elevated plasma corticosterone levels, body weight loss, decrease in proliferation of hippocampal precursor cells; they also inhibited hippocampal cell apoptosis, and exhibited an antidepressant-like effect in a depression-like mouse model induced by CMS. CONCLUSIONS: Our study indicates that each of these CHMs has the potential to ameliorate depression. The possible mechanisms of action include modulation of the HPA axis, reduction in stress hormone levels, inhibition of apoptosis, and promotion of hippocampal neuronal plasticity and neurogenesis. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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