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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chang, Chih-Wei Chen, Yi-Ming Hsu, Yi-Ju Huang, Chi-Chang Wu, Yu-Tse Hsu, Mei-Chich |
| Description | Author Affiliation: Chang CW ( School of Pharmacy, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd, Sanmin Dist., Kaohsiung 80708, Taiwan. Electronic address: wxes9050304@gmail.com.); Chen YM ( Graduate Institute of Sports Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd, Guishan Dist., Taoyuan 33301, Taiwan.); Hsu YJ ( Graduate Institute of Sports Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd, Guishan Dist., Taoyuan 33301, Taiwan.); Huang CC ( Graduate Institute of Sports Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd, Guishan Dist., Taoyuan 33301, Taiwan.); Wu YT ( School of Pharmacy, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd, Sanmin Dist., Kaohsiung 80708, Taiwan. Electronic address: ytwu@kmu.edu.tw.); Hsu MC ( Department of Sports Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd, Sanmin Dist., Kaohsiung 80708, Taiwan. Electronic address: meichich@gmail.com.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Sports anemia is a persistent and severe problem in athletes owing to strenuous exercise-induced oxidative stress and hepcidin upregulation. The roots of Angelica sinensis (AS), a familiar traditional Chinese medicine, has been used for replenishing blood since antiquity. AIM OF THE STUDY: To evaluate the effects of ethanolic AS extract in a 4-week study on sports anemia in female Wistar rats. MATERIALS AND METHODS: To induce anemia, a strenuous exercise protocol consisting of running and swimming was employed with increasing intensity. Animals were randomly assigned to the following groups: control group; strenuous exercise group; and strenuous exercise and AS extract-treated group (300mgkg d ). After 4 weeks, rats underwent exhaustive swimming and forelimb grip strength test. The blood biochemical markers and hepatic antioxidant activities were determined. Hepatic interleukin-6 and muscle glycogen were observed through immunohistochemical and Periodic acid-Schiff staining, respectively. RESULTS: AS extract (consisting of ferulic acid, Z-ligustilide, and n-butylidenephthalide) treatment improved forelimb grip strength and rescued exercise-induced anemia by significantly elevating the red blood cell counts and hemoglobin concentrations as well as hematocrit levels (p<0.05). AS modulated the iron metabolism through decreasing serum hepcidin-25 concentrations by 33.0% (p<0.05) and increasing serum iron levels by 34.3% (p<0.01). The hepatic injury marker serum alanine aminotransferase concentrations were also reduced, followed by increased antioxidant enzyme catalase expression in the liver (p<0.05). Furthermore, substantial attenuation of hepatic interleukin-6 expression and preservation of muscle glycogen content suggested the additional roles of AS acting on sports anemia and physical performance. CONCLUSION: Our findings evidenced a novel and promising therapeutic approach for AS treatment for rescuing the anemic condition induced following 4 weeks of strenuous exercise. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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