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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carpenter, Jessica M. Jourdan, Mary K. Fountain, Emily M. Ali, Zulfiqar Abe, Naohito Khan, Ikhlas A. Sufka, Kenneth J. |
| Description | Country affiliation: United States Author Affiliation: Carpenter JM ( National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.); Jourdan MK ( Department of Psychology, University of Mississippi, University, MS 38677, USA.); Fountain EM ( Department of Psychology, University of Mississippi, University, MS 38677, USA.); Ali Z ( National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.); Abe N ( National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.); Khan IA ( National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.); Sufka KJ ( National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and stress and alleviate pain. AIM OF STUDY: This study sought to examine the effects of an S. tortuosum alkaloid enriched fraction in the chick anxiety-depression model, a model that shows high predictive validity as a pharmacological screening assay. MATERIAL AND METHODS: Socially-raised male Silver Laced Wyandotte chicks (4-6 days old) were given IP vehicle, imipramine (10mg/kg), or S. tortuosum fraction (10, 20, 30mg/kg in Exp. 1 or 50, 75, 100mg/kg in Exp. 2) 15min prior to a 60min isolation test period in which distress vocalizations (DVoc) were continuously recorded. RESULTS: Vehicle chicks displayed high DVoc rates in the anxiety phase (first 3min). DVoc rates declined about 50% (i.e., behavioral despair) in the depression phase (30-60min). S. tortuosum fraction at 75 and 100mg/kg decreased DVoc rates during the anxiety phase indicative of an anxiolytic effect. Imipramine, but not S. tortuosum groups, increased DVoc rates in the depression phase indicative of an antidepressant effect. CONCLUSIONS: The findings suggest that an alkaloid enriched S. tortuosum fraction may benefit some forms of stress-related disorders. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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