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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shwter, Abdrabuh N. Abdullah, Nor Azizan Alshawsh, Mohammed A. El-Seedi, Hesham R. Al-Henhena, Nawal A. Khalifa, Shaden A. M. Abdulla, Mahmood A. |
| Description | Author Affiliation: Shwter AN ( Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: abd_um@yahoo.com.); Abdullah NA ( Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: noraziza@um.edu.my.); Alshawsh MA ( Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: alshaweshmam@um.edu.my.); El-Seedi HR ( Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia); Al-Henhena NA ( Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: nalhenhena@yahoo.com.); Khalifa SA ( Department of Experimental Hematology, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Electronic address: shaden.khalifa.2014@gmail.com.); Abdulla MA ( Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: ammeen@um.edu.my.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Natural products are important ingredients for pharmaceutical applications specifically new entities for treating cancer and other diseases. Phaleria macrocarpa is native of Indonesia and considered as a prolific source of bioactive substances useful for chemoprevention. AIM OF THE STUDY: To investigate the chemopreventive properties of Phaleria macrocarpa on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in rats. METHODS: The biological activities of the ethanol extract of P. macrocarpa fruits were evaluated both in vitro and in vivo. First the extract was investigated for its in vitro antioxidant activity by the total phenolic content and ferric reducing antioxidant power assay. Then the chemopreventive effect of P. macrocarpa was performed on AOM-induced aberrant crypt foci as colorectal carcinoma model in rats. RESULT: the crude ethanolic extract of P. macrocarpa has high antioxidant activity and modulated the oxidative stress as proved by the up-regulation of glutathione-s-transferase and superoxide dismutase. Immunohistochemical staining of the treated sections showed overexpression of PCNA and Bax, reduced crypt sizes and numbers, indicating the characteristic feature of apoptotic cancer cells. PCNA is a landmark of cell damage and turn-over and can be associated with clinical cancer mutation. The most potent doses were 250mg/kg and 500mg/kg as compared to 35mg/kg 5-fluorouracil. CONCLUSION: In this sense, the potential modulation of the colorectal pathophysiological pathway by P. macrocarpa natural compounds mostly flavonoids offer a great possibility for the discovery of new leads towards the colorectal cancer. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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