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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jiang, Zhihui Wang, Jian Li, Xinping Zhang, Xiaoying |
| Description | Author Affiliation: Jiang Z ( College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China); Wang J ( Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi 723000, China.); Li X ( College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.); Zhang X ( College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Male infertility has been increasing over the last decades and being a pressing health problem nowadays. Cistanche tubulosa (CT) is a traditional Chinese medicine used to boost male sexual function. Echinacoside (ECH) is one of the major compounds exist in CT and might be a potential agent to protect testis and sperm injury. AIM OF THE STUDY: To investigate the mechanisms behind the possible protective effects of CT and ECH against testicular and sperm toxicity. MATERIALS AND METHODS: CT was identified by 5.8s gene sequencing. The major compositions (echinacoside and acteoside) of CT were quantified by HPLC method. The adult male Sprague-Dawley rats were exposed to BPA, CT or ECH for 42 consecutive days. The sperm parameters were observed by dark-field microscope; serum hormone levels (FSH, LH and testosterone) were tested by radio immunosorbent; LDH-x activity were evaluated using commercial kits; the expressions of the key steroidogenic enzymes were evaluated by qRT-PCR, heat map, immunofluorescence and western blot. RESULTS: The CT and ECH treatments against BPA-induced testicular and sperm toxicity showed that CT and ECH have reversed BPA-induced abnormality in sperm characteristics, testicular structure and normalized serum testosterone. This was concomitant with the increased expression of LDH-x as well as the key steroidogenic enzymes including StAR, CYP11A1, 3ß-HSD, 17ß-HSD and CYP17A1, suggesting that CT and ECH enhanced testosterone biosynthesis. CONCLUSIONS: CT and ECH attenuated poor sperm quality and testicular toxicity in rats through up-regulation steroidogenesis enzymes and ECH is the active compound of CT as a potential natural reproductive agent. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Journal | Journal of Ethnopharmacology |
| Volume Number | 193 |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-04 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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