NDLI: Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells.

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Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells.

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Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Connolly, Sarah C. Smith, Paul G. Fairbank, Nigel J. Lall, Carolyn A. Cole, Darren J. Mackinnon, James D. Maksym, Geoffrey N.
Description	Country affiliation: Canada Author Affiliation: Connolly SC ( School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada.)
Abstract	A deep inspiration (DI) temporarily relaxes agonist-constricted airways in normal subjects, but in asthma airways are refractory and may rapidly renarrow, possibly due to changes in the structure and function of airway smooth muscle (ASM). Chronic largely uniaxial cyclic strain of ASM cells in culture causes several structural and functional changes in ASM similar to that in asthma, including increases in contractility, MLCK content, shortening velocity, and shortening capacity. However, changes in recovery from acute stretch similar to a DI have not been measured. We have therefore measured the response and recovery to large stretches of cells modified by chronic stretching and investigated the role of MLCK. Chronic, 10% uniaxial cyclic stretch, with or without a strain gradient, was administered for up to 11 days to cultured cells grown on Silastic membranes. Single cells were then removed from the membrane and subjected to 1 Hz oscillatory stretches up to 10% of the in situ cell length. These oscillations reduced stiffness by 66% in all groups (P < 0.05). Chronically strained cells recovered stiffness three times more rapidly than unstrained cells, while the strain gradient had no effect. The stiffness recovery in unstrained cells was completely inhibited by the MLCK inhibitor ML-7, but recovery in strained cells exhibiting increased MLCK was slightly inhibited. These data suggest that chronic strain leads to enhanced recovery from acute stretch, which may be attributable to the strain-induced increases in MLCK. This may also explain in part the more rapid renarrowing of activated airways following DI in asthma.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	4
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Muscle, Smooth Metabolism Physiology Myocytes, Smooth Muscle Myosin-light-chain Kinase Animals Asthma Physiopathology Azepines Pharmacology Cells, Cultured Muscle Contraction Drug Effects Enzymology Antagonists & Inhibitors Naphthalenes Stress, Mechanical Trachea Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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