NDLI: Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral artery ligated rats

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McCord, Jennifer L. Tsuchimochi, Hirotsugu Yamauchi, Katsuya Leal, Anna Kaufman, Marc P.
Description	Country affiliation: United States Author Affiliation: McCord JL ( Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.)
Abstract	In decerebrate rats, we reported previously that the exercise pressor reflex arising from a limb whose femoral artery was occluded for 72 h before the experiment was significantly higher than the exercise pressor reflex arising from a contralateral freely perfused limb. These findings prompted us to examine whether reactive oxygen species contributed to the augmented pressor reflex in rats with femoral artery occlusion. We found that the pressor reflex arising from the limb whose femoral artery was occluded for 72 h before the experiment (31 ± 5 mmHg) was attenuated by tempol (10 mg), a superoxide dismutase (SOD) mimetic (18 ± 5 mmHg, n = 9, P < 0.05), that was injected into the arterial supply of the hindlimb. In contrast, the pressor reflex arising from a freely perfused hindlimb (20 ± 3 mmHg) was not attenuated by tempol (17 ± 4 mmHg, n = 10, P = 0.49). Nevertheless, we found no difference in the increase in 8-isoprostaglandin F(2 ) levels, an index of reactive oxygen species, in response to contraction between freely perfused (3.76 ± 0.82 pg/ml, n = 19) and 72-h occluded (3.51 ± 0.92 pg/ml, n = 22, P = 0.90) hindlimbs. Moreover, tempol did not reduce the 8-isoprostaglandin F(2 ) levels during contraction in either group (P > 0.30). A second SOD mimetic, tiron (200 mg/kg), had no effect on the exercise pressor reflex in either the rats with freely perfused hindlimbs or in those with occluded femoral arteries. These findings suggest that tempol attenuated the exercise pressor reflex in the femoral artery-occluded hindlimb by a mechanism that was independent of its ability to scavenge reactive oxygen species.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.00535.2011
Journal	Journal of Applied Physiology
Issue Number	4
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Cyclic N-oxides Pharmacology Femoral Artery Drug Effects Reactive Oxygen Species Metabolism 1,2-dihydroxybenzene-3,5-disulfonic Acid Disodium Salt Animals Decerebrate State Dinoprost Analogs & Derivatives Surgery Hindlimb Physiology Ligation Muscle Contraction Muscle, Skeletal Physical Conditioning, Animal Rats, Sprague-dawley Spin Labels Superoxide Dismutase Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral artery ligated rats

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