NDLI: Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peng, Ying-Jie Raghuraman, Gayatri Khan, Shakil A. Kumar, Ganesh K. Prabhakar, Nanduri R.
Description	Country affiliation: United States Author Affiliation: Peng YJ ( Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA.)
Abstract	We previously reported that reactive oxygen species generated by NADPH oxidase 2 (Nox2) induces sensory plasticity of the carotid body, manifested as a progressive increase in baseline sensory activity or sensory long-term facilitation (sLTF). ANG II, a peptide generated within the carotid body, is a potent activator of Nox2. In the present study, we tested the hypothesis that ANG II evokes sLTF of the carotid body via Nox2 activation. Experiments were performed on carotid bodies ex vivo from adult rats and mice. Sensory activity was recorded from the carotid sinus nerve. Repetitive (5 times for 30 s each at 5-min intervals), but not continuous (for 150 s), application of 60 pM ANG II evoked robust sLTF of the carotid body. ACh, ATP, substance P, and KCl, when applied repetitively, stimulated the carotid body but did not evoke sLTF. Reactive oxygen species levels increased in response to repetitive applications of ANG II, and this effect was blocked by apocynin, an inhibitor of Nox2, as well as losartan, an angiotensin type 1 (AT(1)) receptor antagonist. Losartan, apocynin, and 4-(2-aminoethyl)benzenesulfonyl fluoride prevented ANG II-induced sLTF, which was absent in mice deficient in gp91(phox), the catalytic subunit of the Nox2 complex. These results demonstrate that repetitive application of ANG II induces sLTF of the carotid body via activation of Nox2 by AT(1) receptors.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.00022.2011
Journal	Journal of Applied Physiology
Issue Number	4
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Angiotensin Ii Metabolism Pharmacology Carotid Body Nadph Oxidase Acetylcholine Adenosine Triphosphate Animals Drug Effects Carotid Sinus Mice Potassium Chloride Rats, Sprague-dawley Reactive Oxygen Species Receptor, Angiotensin, Type 1 Substance P Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase

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