NDLI: Depressed contractile performance and reduced fatigue resistance in single skinned fibers of soleus muscle after long-term disuse in rats.

Please wait, while we are loading the content...

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions

What's in a number?

Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not.

Tolerance to central hypovolemia: the influence of oscillations in arterial pressure and cerebral blood velocity.

Effects of high- and low-velocity resistance training on the contractile properties of skeletal muscle fibers from young and older humans.

Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes.

Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography.

Metoprolol impairs resistance artery function in mice.

Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice.

Exercise training increases mitochondrial biogenesis in the brain.

The 7ß1-integrin increases muscle hypertrophy following multiple bouts of eccentric exercise.

Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies.

Perspective in comparisons of skin versus muscle blood flow.

Serotonin and SIDS.

Year: 2011 Volume: 111 Issue: 3

Year: 2011 Volume: 111 Issue: 2

Year: 2011 Volume: 111 Issue: 1

Year: 2011 Volume: 110

Year: 2010 Volume: 109

Year: 2010 Volume: 108

Year: 2009 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2008 Volume: 104

Year: 2007 Volume: 103

Year: 2007 Volume: 102

Year: 2006 Volume: 101

Year: 2006 Volume: 100

Year: 2005 Volume: 99

Year: 2005 Volume: 98

Year: 2004 Volume: 97

Year: 2004 Volume: 96

Year: 2003 Volume: 95

Year: 2002 Volume: 93

Year: 2002 Volume: 92

Year: 2000 Volume: 89

Year: 2000 Volume: 88

Year: 1991 Volume: 70

Depressed contractile performance and reduced fatigue resistance in single skinned fibers of soleus muscle after long-term disuse in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Udaka, Jun Terui, Takako Ohtsuki, Iwao Marumo, Keishi Ishiwata, Shin'ichi Kurihara, Satoshi Fukuda, Norio
Description	Country affiliation: Japan Author Affiliation: Udaka J ( Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan.)
Abstract	Long-term disuse results in atrophy in skeletal muscle, which is characterized by reduced functional capability, impaired locomotor condition, and reduced resistance to fatigue. Here we show how long-term disuse affects contractility and fatigue resistance in single fibers of soleus muscle taken from the hindlimb immobilization model of the rat. We found that long-term disuse results in depression of caffeine-induced transient contractions in saponin-treated single fibers. However, when normalized to maximal Ca(2+)-activated force, the magnitude of the transient contractions became similar to that in control fibers. Control experiments indicated that the active force depression in disused muscle is not coupled with isoform switching of myosin heavy chain or troponin, or with disruptions of sarcomere structure or excessive internal sarcomere shortening during contraction. In contrast, our electronmicroscopic observation supported our earlier observation that interfilament lattice spacing is expanded after disuse. Then, to investigate the molecular mechanism of the reduced fatigue resistance in disused muscle, we compared the inhibitory effects of inorganic phosphate (Pi) on maximal Ca(2+)-activated force in control vs. disused fibers. The effect of Pi was more pronounced in disused fibers, and it approached that observed in control fibers after osmotic compression. These results suggest that contractile depression in disuse results from the lowering of myofibrillar force-generating capacity, rather than from defective Ca(2+) mobilization, and the reduced resistance to fatigue is from an enhanced inhibitory effect of Pi coupled with a decrease in the number of attached cross bridges, presumably due to lattice spacing expansion.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	4
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Fatigue Physiopathology Muscle Contraction Physiology Muscle Fibers, Skeletal Muscular Disorders, Atrophic Myofibrils Animals Caffeine Pharmacology Calcium Metabolism Hindlimb Suspension Drug Effects Myosin Heavy Chains Osmotic Pressure Phosphates Rats, Wistar Saponins Sarcomeres Troponin Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Skeletal muscle contractile protein function is preserved in human heart failure.

Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers.

Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex.

The role of myostatin and activin receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy.

Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia

Altered myoplasmic $Ca^{2+}$ handling in rat fast-twitch skeletal muscle fibres during disuse atrophy

Effects of carnosine on contractile apparatus Ca²âº sensitivity and sarcoplasmic reticulum Ca²âº release in human skeletal muscle fibers.

Contractile properties of the isolated rat soleus muscle and its single skinned soleus fibers at the early stage of gravitational unloading: Facts and hypotheses

Inactivity, age, and exercise: single-muscle fiber power generation

Depressed contractile performance and reduced fatigue resistance in single skinned fibers of soleus muscle after long-term disuse in rats.

Similar Documents

Skeletal muscle contractile protein function is preserved in human heart failure.

Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers.

Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex.

The role of myostatin and activin receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy.

Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia

Altered myoplasmic $Ca^{2+}$ handling in rat fast-twitch skeletal muscle fibres during disuse atrophy

Effects of carnosine on contractile apparatus Ca²âº sensitivity and sarcoplasmic reticulum Ca²âº release in human skeletal muscle fibers.

Contractile properties of the isolated rat soleus muscle and its single skinned soleus fibers at the early stage of gravitational unloading: Facts and hypotheses

Inactivity, age, and exercise: single-muscle fiber power generation

Depressed contractile performance and reduced fatigue resistance in single skinned fibers of soleus muscle after long-term disuse in rats.

Effects of carnosine on contractile apparatus Ca²âº sensitivity and sarcoplasmic reticulum Ca²âº release in human skeletal muscle fibers.