NDLI: Total and specific IgE associations between New York City Head Start children and their parents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Canfield, Stephen M. Jacobson, Judith S. Perzanowski, Matthew S. Mellins, Robert B. Zemble, Robert M. Chew, Ginger L. Goldstein, Inge F.
Spatial Coverage	New York City
Description	Country affiliation: United States Author Affiliation: Canfield SM ( Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8 East, Suite 101, 622 West 168th St, New York, NY 10032, USA. smc12@columbia.edu)
Abstract	BACKGROUND: Allergy and asthma risk share strong inherited components; however, the relative importance of maternal and paternal atopy in predicting child atopy remain unclear. OBJECTIVE: We sought to identify relationships between parents' and children's total and specific IgE levels within family units as predictors of allergic risk in children. METHODS: Total and allergen-specific IgE (to dust mite, cockroach, mouse, and cat) were determined by means of ImmunoCap (Phadia, Inc, Portage, Mich) in a sample of families participating in New York City Head Start programs. Regression models were developed to determine the associations of parents' and children's total IgE levels and sensitization patterns. RESULTS: Blood specimens were collected from 161 family triads of mother, father, and child (83 boys and 78 girls). At a mean age of 4 years, boys had significantly higher total IgE levels than girls. Boys' total IgE levels were highly correlated with both mothers' (P < .002) and fathers' (P = .002) total IgE levels; girls' total IgE levels were not. Unlike total IgE levels, specific IgE levels among both boys and girls were associated with their mothers' specific IgE levels. Dust mite sensitization among mothers was predictive of children's sensitization to each of the 4 aeroallergens. CONCLUSION: The strong associations between parents' and children's IgE levels suggest that assessment of parents' total and locally relevant allergen-specific IgE levels might have value in predicting atopy in children of preschool age.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	6
Volume Number	121
Language	English
Publisher	Elsevier
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Genetic Predisposition To Disease Hypersensitivity, Immediate Blood Genetics Immunoglobulin E Allergens Immunology Child, Preschool Early Intervention (education) Pedigree Risk Factors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Asthma, allergy, and IgE levels in NYC head start children.

Pattern of allergen-specific IgE sensitization relative to total serum IgE concentration in young adults.

Specific allergic sensitization in parents and their 18-year-old offspring in the Suburban Detroit Childhood Allergy Study.

Children in the inner city of New York have high rates of food allergy and IgE sensitization to common foods.

The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food.

Physical activity and asthma symptoms among New York City Head Start Children.

Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy.

Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens.

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort.

Total and specific IgE associations between New York City Head Start children and their parents.

Similar Documents

Asthma, allergy, and IgE levels in NYC head start children.

Pattern of allergen-specific IgE sensitization relative to total serum IgE concentration in young adults.

Specific allergic sensitization in parents and their 18-year-old offspring in the Suburban Detroit Childhood Allergy Study.

Children in the inner city of New York have high rates of food allergy and IgE sensitization to common foods.

The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food.

Physical activity and asthma symptoms among New York City Head Start Children.

Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy.

Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens.

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort.

Total and specific IgE associations between New York City Head Start children and their parents.