NDLI: Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elias, Peter M. Hatano, Yutaka Williams, Mary L.
Description	Country affiliation: United States Author Affiliation: Elias PM ( Dermatology Service, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA. eliasp@derm.ucsf.edu)
Abstract	Until quite recently, the pathogenesis of atopic dermatitis (AD) has been attributed to primary abnormalities of the immune system. Intensive study revealed the key roles played by T(H)1/T(H)2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes AD. Accordingly, current therapy has been largely directed toward ameliorating T(H)2-mediated inflammation and pruritus. In this review we will assess emerging evidence that inflammation in AD results from inherited and acquired insults to the barrier and the therapeutic implications of this paradigm.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2008.01.022
Journal	Journal of Allergy and Clinical Immunology
Issue Number	6
Volume Number	121
Language	English
Publisher	Elsevier
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Dermatitis, Atopic Immunology Skin Pathology Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms.