NDLI: Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Please wait, while we are loading the content...

Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients.

Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function.

How predictive are predictors of remission of peanut allergy?

When should consideration be given to referring a patient with chronic rhinosinusitis to an ear, nose, and throat specialist?

Total and specific IgE associations between New York City Head Start children and their parents.

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes.

The role of protein digestibility and antacids on food allergy outcomes.

T(H)2 adjuvants: implications for food allergy.

Epidemiologic risks for food allergy.

Advances in environmental and occupational respiratory disease in 2007.

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma.

Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI).

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.

Impairment of T-regulatory cells in cord blood of atopic mothers.

Inducing an anergic state in mast cells and basophils without secretion.

The value of sesame-specific IgE levels in predicting sesame allergy.

Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms.

Food allergens: landmarks along a historic trail.

Year: 2008 Volume: 121 Issue: 5

Year: 2008 Volume: 121 Issue: 4

Year: 2008 Volume: 121 Issue: 3

Year: 2008 Volume: 121 Issue: 2

Year: 2008 Volume: 121 Issue: 2 Supplementary

Year: 2008 Volume: 121 Issue: 1

Year: 2007 Volume: 120

Year: 2007 Volume: 119

Year: 2006 Volume: 118

Year: 2006 Volume: 117

Year: 2005 Volume: 116

Year: 2005 Volume: 115

Year: 2004 Volume: 113

Year: 2001 Volume: 108

Year: 2000 Volume: 106

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kato, Atsushi Peters, Anju Suh, Lydia Carter, Roderick Harris, Kathleen E. Chandra, Rakesh Conley, David Grammer, Leslie C. Kern, Robert Schleimer, Robert P.
Description	Country affiliation: United States Author Affiliation: Kato A ( Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA.)
Abstract	BACKGROUND: The polypoid form of chronic rhinosinusitis (chronic rhinosinusitis with nasal polyps [CRSwNP]) is a highly prevalent disease that often requires surgical intervention for treatment. Nasal polyps contain large quantities of B lymphocytes and immunoglobulin as well as eosinophils. OBJECTIVES: The objective of this study was to investigate the expression of B cell-activating factor of the TNF family (BAFF), an important regulator of class-switch recombination and immunoglobulin production, in patients with chronic rhinosinusitis (CRS). METHODS: We collected nasal tissue and nasal lavage fluid from patients with CRS and control subjects. We assayed mRNA for BAFF and B-lymphocyte markers, CD20 and transmembrane activator and calcium-modulator and cyclophilin ligand interactor, by using real-time PCR, and assayed BAFF protein by using ELISA and immunohistochemistry. RESULTS: BAFF mRNA was significantly increased in nasal polyps from patients with CRSwNP (P < .001) compared with inferior turbinate tissue from patients with CRS or healthy subjects. BAFF protein was also elevated in polypoid tissue and nasal lavage from patients with CRSwNP. Immunohistochemistry showed considerable BAFF staining in mucosal epithelial cells in nasal polyps along with unidentified cells in the lamina propria. Expression of mRNA for BAFF in sinonasal tissue was significantly correlated with CD20 and transmembrane activator and CAML interactor in sinus tissue. IgA, an immunoglobulin isotype known to activate eosinophils, was also significantly elevated in the polypoid tissue. CONCLUSION: Overproduction of BAFF in nasal polyps may contribute to the pathogenesis of CRSwNP via the local induction of IgA and activation of eosinophils.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2008.03.002
Journal	Journal of Allergy and Clinical Immunology
Issue Number	6
Volume Number	121
Language	English
Publisher	Elsevier
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology B-cell Activating Factor Biosynthesis Nasal Polyps Metabolism Rhinitis Sinusitis Chronic Disease Enzyme-linked Immunosorbent Assay Immunoglobulin A Immunology Immunohistochemistry Nasal Lavage Fluid Chemistry Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor Ligand Superfamily Member 13 Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis.

Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps.

Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps

Age-related differences in the pathogenesis of chronic rhinosinusitis.

Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.

Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps.

Emerging biologics for the treatment of chronic rhinosinusitis.

BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.

Up-regulation of Chemokine Ligand 20 in Chronic Rhinosinusitis

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Similar Documents

Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis.

Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps.

Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps

Age-related differences in the pathogenesis of chronic rhinosinusitis.

Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.

Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps.

Emerging biologics for the treatment of chronic rhinosinusitis.

BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.

Up-regulation of Chemokine Ligand 20 in Chronic Rhinosinusitis

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.