NDLI: Specific allergic sensitization in parents and their 18-year-old offspring in the Suburban Detroit Childhood Allergy Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Misiak, Rana Tawil Wegienka, Ganesa Havstad, Suzanne Ownby, Dennis R. Johnson, Christine Cole Zoratti, Edward M.
Spatial Coverage	Michigan
Description	Country affiliation: United States Author Affiliation: Misiak RT ( Department of Internal Medicine, Division of Allergy, Henry Ford Hospital, Henry Ford Health System, Detroit, MI 48202, USA. rmisiak1@hfhs.org)
Abstract	BACKGROUND: Allergic sensitization is increased among offspring of sensitized parents. OBJECTIVE: We sought to evaluate whether 18-year-old offspring are likely to have the same allergic sensitizations as their parents. METHODS: Eighteen-year-old participants in an unselected birth cohort and their parents were tested for total and increased (>0.35 kU/L) levels of allergen-specific IgE to 6 allergens: Dermatophagoides farinae, dog, cat, grass, ragweed, and Alternaria alternata. RESULTS: In 316 parent-teen triads parental sensitization to any of 6 allergens was associated with teen sensitization to any of those same allergens. An increased risk of matched sensitization (ie, a teen has an increased risk of being sensitized to the same specific allergen as their parent) was found after adjusting for the spouse's sensitivities and adjusting for other allergens (ie, the parent had an allergic sensitization but not to the particular allergen under analysis). Risk of maternal matched sensitization with their teen to cat (adjusted odds ratio [aOR], 2.1; 95% CI, 1.0-4.5), grass (aOR, 2.5; 95% CI, 1.2-5.2), and A alternata (aOR, 2.4; 95% CI, 1.1-5.5) was increased when compared with that seen in teens without parental allergen-specific sensitization. Similarly, a higher than expected risk of paternal matched sensitization with their teen to dog (aOR, 2.7; 95% CI, 1.3-5.9), D farinae (aOR, 2.7; 95% CI, 1.4-5.1), and grass (aOR, 2.7; 95% CI, 1.5-5.9) was observed. CONCLUSION: Parental allergen-specific IgE increases the likelihood of sensitization to the same allergen in young adult offspring.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2009.03.006
Journal	Journal of Allergy and Clinical Immunology
Issue Number	6
Volume Number	123
Language	English
Publisher	Elsevier
Publisher Date	2009-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Allergens Immunology Hypersensitivity Epidemiology Immunoglobulin E Blood Adolescent Adult Children Child, Preschool Infant Infant, Newborn Michigan Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Specific allergic sensitization in parents and their 18-year-old offspring in the Suburban Detroit Childhood Allergy Study.