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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Klapec, T. Sarkanj, B. Banjari, I. Strelec, I. |
| Description | Country affiliation: Croatia Author Affiliation: Klapec T ( Faculty of Food Technology, Josip Juraj Strossmayer University, Osijek, Croatia. tomi@ptfos.hr) |
| Abstract | This study determined exposure of pregnant women to ochratoxin A (OTA). Forty samples of first-void urine samples from Croatian women in the third trimester of pregnancy were analyzed for OTA and its major metabolite ochratoxin alpha (OT ). The subjects filled a short food frequency questionnaire (FFQ). Analysis was performed by HPLC-FLD following liquid-liquid extraction. All samples were subjected in parallel to enzymatic treatment (ß-glucuronidase/aryl sulfatase) to release OTA and OT from the conjugates. The median urinary levels of OTA and OT before treatment were 0.02 (range: nd-1.07) ng/mL and 0.16 (nd-1.86) ng/mL; the concentrations after enzyme hydrolysis were 0.02 (nd-1.11) ng/mL and 1.18 (0.11-7.57) ng/mL. While OT levels increased significantly following enzymatic treatment, evidence for OTA conjugation was weak. The ratio of urinary OT medians after and before hydrolysis was 1.5 times higher than previously reported for nonpregnant female subjects, possibly indicating upregulated metabolism and/or elimination of the mycotoxin and metabolites in pregnancy. The mean daily dietary OTA intake calculated from FFQs (1.08±0.57 ng/kg body weight) was well below the provisional tolerable daily intake and the greatest contributors to intake were cereal products, fruit juices, chocolate and coffee. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 12 |
| Volume Number | 50 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Beverages Analysis Diet Food Contamination Ochratoxins Urine Adult Animals Cacao Chemistry Microbiology Chromatography, High Pressure Liquid Coffee Creatinine Cereals Female Food Handling Food Microbiology Fruit Humans Meat Products Pregnancy Questionnaires Swine Vitis Wine Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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