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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Viyoch, Jarupa Mahingsa, Khuanrudee Ingkaninan, Kornkanok |
| Description | Country affiliation: Thailand Author Affiliation: Viyoch J ( Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand. jarupav@nu.ac.th) |
| Abstract | The effects of oral administration of Musa sapientum and Musa suerier on prevention of UVB induced skin damages were investigated in male ICR mice. Animals were orally administered 50mg/day ascorbic acid, or M. sapientum or M. suerier's fruit pulps at dose of 0.5, 1 or 1.5 mg/g body weight/day for 12 weeks. Concurrently, the shaved backs of animals were irradiated with UVB for 12weeks. The intensity of irradiation was progressively increased, from 54 mJ/cm(2) per exposure at week 1-126 mJ/cm(2) at week 11. A significant decrease (p<0.05) in skin elasticity (from 0.82±0.02 to 0.42±0.09) and total glutathione (from (193.6±18.7 to 152.7±7.8 ng/mg protein) as compared with the control group (water-administered UVB-irradiated mice) was observed after 12 weeks of UVB exposure. When L-ascorbic acid (0.72±0.01) or 1mg/g body weight/day M. suerier (0.84±0.06) were administered to UVB-irradiated mice, the reduction in skin elasticity was significantly inhibited (p<0.05). Moreover, the significant increase (p<0.05) in level of total glutathione was found in these groups (220.8±13.3 ng/mg protein for l-ascorbic acid and 224.9±20.1 ng/mg protein for M. suerier). These findings suggest the potential effect of daily consumption of M. suerier on prevention of skin damage from repeated UVB exposure. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 12 |
| Volume Number | 50 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Musa Chemistry Plant Extracts Pharmacology Skin Drug Effects Radiation Effects Ultraviolet Rays Adverse Effects Administration, Oral Animals Ascorbic Acid Administration & Dosage Free Radical Scavengers Glutathione Metabolism Immunohistochemistry Male Mice Mice, Inbred Icr Phenols Analysis Pathology Skin Diseases Transforming Growth Factor Beta1 Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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