NDLI: Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.

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Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Tae-Won Song, In-Bae Lee, Hong-Ki Lim, Jong-Hwan Cho, Eun-Sang Son, Hwa-Young Park, Sang-Jin Kim, Jong-Woo Yun, Hyo-In
Description	Author Affiliation: Kim TW ( College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon, Republic of Korea.)
Abstract	Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5 mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity.
File Format	HTM / HTML
ISSN	02786915
Issue Number	12
Volume Number	50
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2012-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Cisplatin Toxicity Kidney Diseases Drug Therapy Kidney Drug Effects Platycodon Chemistry Saponins Pharmacology Triterpenes Animals Apoptosis Blood Urea Nitrogen Creatinine Blood Glutathione Metabolism Glutathione Peroxidase Pathology Lipid Peroxidation Male Mice Mice, Inbred Icr Nf-kappa B Nitric Oxide Oxidative Stress Plant Roots Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.