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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dupont, Christophe Hol, Jeroen Nieuwenhuis, Edward E. S. |
| Spatial Coverage | Netherlands |
| Description | Country affiliation: France Author Affiliation: Dupont C ( Department of Pediatric Gastroenterology,Hepatology and Nutrition, Service d'Explorations Fonctionnelles Digestives Pédiatriques, Hôpital Necker-Enfants Malades,149 rue de Sèvres,75015Paris,France.); Hol J ( Department of Pediatrics,St Elisabeth Hospital,Willemstad, Curaçao,The Netherlands Antilles.); Nieuwenhuis EE ( Department of Pediatrics,Wilhelmina Children's Hospital, University Medical Center Utrecht,Utrecht,The Netherlands.) |
| Abstract | Children with cows' milk protein allergy (CMPA) are at risk of insufficient length and weight gain, and the nutritional efficacy of hypo-allergenic formulas should be carefully assessed. In 2008, a trial assessed the impact of probiotic supplementation of an extensively hydrolysed casein-based formula (eHCF) on acquisition of tolerance in 119 infants with CMPA. First analysis of the study results showed that the studied formula allowed improvement of food-related symptoms. The scoring of atopic dermatitis (SCORAD) index was assessed at randomisation and after 6 months of feeding. A post hoc analysis was performed using WHO growth software's nutritional survey module (WHO Anthro version 3.2.2). All infants who were fed the study formula tolerated it well. The SCORAD index significantly improved from randomisation to 6 months of feeding with the study formula. Anthropometric data indicated a significant improvement in the weight-for-age, length-for-age and weight-for-length z scores, as well as in the restoration of normal BMI. The probiotic supplementation did not show any impact on these parameters. The present data showed that this eHCF was clinically tolerated and significantly improved the SCORAD index and growth indices. |
| File Format | HTM / HTML |
| ISSN | 00071145 |
| Issue Number | 7 |
| Volume Number | 113 |
| e-ISSN | 14752662 |
| Journal | British Journal of Nutrition |
| Language | English |
| Publisher | Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date | 2015-04-14 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Discipline Sciences Caseins Therapeutic Use Child Development Foods, Specialized Immune Tolerance Infant Formula Chemistry Milk Hypersensitivity Diet Therapy Bifidobacterium Immunology Body Mass Index Adverse Effects Dermatitis, Atopic Epidemiology Etiology Prevention & Control Double-blind Method Female Follow-up Studies Microbiology Humans Infant Infant Nutritional Physiological Phenomena Lactobacillus Casei Lost To Follow-up Male Physiopathology Netherlands Patient Dropouts Probiotics Risk Thinness Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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