| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Kuntz, Sabine Rudloff, Silvia Asseburg, Heike Borsch, Christian Fröhling, Bettina Unger, Franziska Dold, Sebastian Spengler, Bernhard Römpp, Andreas Kunz, Clemens |
| Spatial Coverage |
Germany |
| Description |
Country affiliation: Germany Author Affiliation: Kuntz S ( Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany.); Rudloff S ( Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany.); Asseburg H ( Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany.); Borsch C ( Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany.); Fröhling B ( Geisenheim Research Center, Section of Wine Analysis and Beverage Technology,Geisenheim,Germany.); Unger F ( Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University,Giessen,Germany.); Dold S ( Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University,Giessen,Germany.); Spengler B ( Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University,Giessen,Germany.); Römpp A ( Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University,Giessen,Germany.); Kunz C ( Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany.) |
| Abstract |
The goal of eating five servings of fruits and vegetables a day has not yet been achieved. The intake of polyphenols such as anthocyanins (ACN) could be improved by consuming smoothies and juices that are increasingly popular, especially in children; however, bioavailability data concerning food matrix effects are scarce. Thus, we conducted a randomised, cross-over, bioavailability study (n 10) to determine the bioavailability of ACN and their metabolites from an ACN-rich grape/blueberry juice (841 mg ACN/litre) and smoothie (983 mg ACN/litre) in vivo, and the uptake of a corresponding grape/blueberry extract in vitro. After the intake of beverage (0·33 litres), plasma and fractionated urine samples were collected and analysed by ultra-performance liquid chromatography coupled to MS. The most abundant ACN found in plasma and urine were malvidin and peonidin as native ACN and as glucuronidated metabolites as well as 3,4-dihydroxybenzoic acid (3,4-DHB); minor ACN (delphinidin, cyanidin and petunidin) were only detected as native glycosides. Plasma pharmacokinetics and recoveries of urinary metabolites of ACN were not different for juice or smoothie intake; however, the phenolic acid 3,4-DHB was significantly better bioavailable from juice in comparison to smoothie. In vitro data with absorptive intestinal cells indicated that despite their weak chemical stability, ACN and 3,4-DHB could be detected at the basal side in their native forms. Whether smoothies as well as juices should be recommended to increase the intake of potentially health-promoting ACN and other polyphenols requires the consideration of other ingredients such as their relatively high sugar content. |
| File Format |
HTM / HTML |
| ISSN |
00071145 |
| Issue Number |
7 |
| Volume Number |
113 |
| e-ISSN |
14752662 |
| Journal |
British Journal of Nutrition |
| Language |
English |
| Publisher |
Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date |
2015-04-14 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Nutritional Discipline Sciences Anthocyanins Metabolism Antioxidants Beverages Food, Organic Fruit Chemistry Hydroxybenzoates Phenols Adult Blood Urine Analysis Blueberry Plant Caco-2 Cells Cross-over Studies Double-blind Method Female Germany Glucuronides Humans Hydroxylation Intestinal Absorption Male Plant Extracts Vitis Young Adult Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Nutrition and Dietetics Medicine |
