NDLI: Dietary linoleic acid requirements in the presence of -linolenic acid are lower than the historical 2 % of energy intake value, study in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Choque, Benjamin Catheline, Daniel Delplanque, Bernadette Guesnet, Philippe Legrand, Philippe
Description	Country affiliation: France Author Affiliation: Choque B ( Laboratoire de Biochimie et Nutrition Humaine,INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc,35042Rennes Cedex,France.); Catheline D ( Laboratoire de Biochimie et Nutrition Humaine,INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc,35042Rennes Cedex,France.); Delplanque B ( UMR 8195 CNPS - Centre de Neurosciences Paris-Sud, NMPA - Neuroendocrinologie Moléculaire de la Prise Alimentaire, Université Paris-Sud XI,Orsay,France.); Guesnet P ( PG Consulting,13 Villa Bellevue,Bures sur Yvette,France.); Legrand P ( Laboratoire de Biochimie et Nutrition Humaine,INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc,35042Rennes Cedex,France.)
Abstract	Previous studies on rats and human subjects have established that the linoleic acid (LA) requirement is 2 % of the total energy intake (en%), but is obtained in the absence of -linolenic acid (ALA) and consequently appear to be overestimated. This raises questions since a recent study including ALA has suggested to divide the historical value by four. However, this recent study has remained inconclusive because the animals used were not totally LA-deficient animals. For the first time, the present study was especially designed using physiological and biochemical markers and performed in two steps: (1) to achieve a specific n-6 fatty acid deficiency model using growing male rats fed either a 0 en% from LA/0 en% from ALA (0LA/0ALA), 0LA/0·5ALA or 2LA/0·5ALA diet, born from female rats fed a 0LA/0·5ALA diet; and (2) to refine the required level of LA in the presence of ALA using rats fed either a 0LA/0ALA, 0·5LA/0·5ALA, 1LA/0·5ALA, 1·5LA/0·5ALA diet, born from female rats fed a 0LA/0·5ALA diet. The first step shows that the best LA deficiency model was obtained using rats fed the 0LA/0ALA diet, born from female rats fed the 0LA/0·5ALA diet. The second step demonstrates that in growing rats, LA deficiency was corrected with an intake of 1-1·5 en% from LA and 0·5 en% from ALA. These data suggest that the requirements in humans should be revisited, considering the presence of ALA to set up the recommendation for LA.
File Format	HTM / HTML
ISSN	00071145
Issue Number	7
Volume Number	113
e-ISSN	14752662
Journal	British Journal of Nutrition
Language	English
Publisher	Cambridge University Press (on behalf of The Nutrition Society)
Publisher Date	2015-04-14
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Discipline Sciences Deficiency Diseases Prevention & Control Disease Models, Animal Energy Intake Linoleic Acid Therapeutic Use Nutritional Requirements Alpha-linolenic Acid Administration & Dosage Animals Biological Markers Diet Therapy Physiopathology Female Fetal Development Lactation Deficiency Metabolism Male Maternal Nutritional Physiological Phenomena Pregnancy Random Allocation Rats, Wistar Skin Diseases, Metabolic Etiology Tail Weaning Weight Gain Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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