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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yu, Huan-Ling Dong, Shan Gao, Li-Fang Li, Li Xi, Yuan-Di Ma, Wei-Wei Yuan, Lin-Hong Xiao, Rong |
| Description | Author Affiliation: Yu HL ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Dong S ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Gao LF ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Li L ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Xi YD ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Ma WW ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Yuan LH ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.); Xiao R ( School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University,Beijing100069,People's Republic of China.) |
| Abstract | An epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease in offspring. The present study aimed to observe the effects of a maternal high-lipid, high-energy (HLE) diet on the DNA methylation pattern of male offspring in mice. Female C57BL/6J mice were fed an HLE diet during gestation and lactation. The genomic DNA methylations at promoter sites of genes in the liver, mRNA and protein levels of selected genes related to lipid and glucose metabolism were measured by microarray, real-time PCR and Western blot. The results indicated that the percentage of methylated DNA in offspring from dams that were fed an HLE diet was significantly higher than that from dams that were fed a chow diet, and most of these genes were hypermethylated in promoter regions. The nuclear protein content and mRNA levels of hypermethylated genes, such as PPARγ and liver X receptor (LXR ), were decreased significantly in offspring in the HLE group. The results suggested that the DNA methylation profile in adult offspring livers was changed by the maternal HLE diet during gestation and lactation. |
| File Format | HTM / HTML |
| ISSN | 00071145 |
| Issue Number | 7 |
| Volume Number | 113 |
| e-ISSN | 14752662 |
| Journal | British Journal of Nutrition |
| Language | English |
| Publisher | Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date | 2015-04-14 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Discipline Sciences Dna Methylation Diet, High-fat Adverse Effects Energy Intake Epigenesis, Genetic Liver Metabolism Maternal Nutritional Physiological Phenomena Up-regulation Animals Female Fetal Development Gene Expression Regulation, Developmental Lactation Growth & Development Male Mice, Inbred C57bl Pregnancy Promoter Regions, Genetic Rna, Messenger Random Allocation Specific Pathogen-free Organisms Weaning Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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