NDLI: Secondary bladder amyloidosis with familial Mediterranean fever in a living donor kidney transplant recipient: a case report

Content Provider	Springer Nature : BioMed Central
Author	Imamura, Sentaro Narita, Shintaro Nishikomori, Ryuta Tsuruta, Hiroshi Numakura, Kazuyuki Maeno, Atsushi Saito, Mitsuru Inoue, Takamitsu Tsuchiya, Norihiko Nanjo, Hiroshi Heike, Toshio Satoh, Shigeru Habuchi, Tomonori
Abstract	Background Secondary bladder amyloidosis is an extremely rare disease, resulting from a chronic systematic inflammatory disorder associated with amyloid deposits. Although uncommon in Japan, familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent episodes of fever of short duration and serositis and is frequently associated with systemic amyloidosis. Here, we present a case of a Japanese patient complaining of fever and macroscopic hematuria after a living donor renal transplantation. Consequently, he was diagnosed with secondary bladder amyloidosis with FMF. Case presentation A 64-year-old Japanese male received a living ABO-incompatible kidney transplant from his wife. The postoperative clinical course was normal, and the patient was discharged 21 days after the transplantation with a serum creatinine level of 0.78 mg/dl. The patient frequently complained of general fatigue and fever of unknown origin. Six months later, the patient presented with continuous general fatigue, macroscopic hematuria, and fever. Cystoscopic examination of the bladder showed an edematous region with bleeding, and a transurethral biopsy revealed amyloid deposits. His wife stated that the patient had a recurrent high fever since the age of 40 years and that his younger brother was suspected to have a familial autoinflammatory syndrome; thus, the patient was also suspected to have a familial autoinflammatory syndrome. Based on his brother’s medical history and the genetic tests, which showed a homozygous mutation (M694V/M694V) for the Mediterranean fever protein, he was diagnosed with FMF. Although colchicine treatment for FMF was planned, the patient had an untimely death due to heart failure. We re-evaluated the pathological findings of the various tissue biopsies obtained during the treatment after the renal transplantation. Immunohistochemistry revealed amyloid deposits in the bladder region, renal allograft, and myocardium and the condition was diagnosed as AA amyloidosis associated with FMF. Conclusion We presented a case of systemic amyloidosis with FMF, involving the bladder region, myocardium, and renal allograft, diagnosed after renal transplantation. Bladder amyloidosis should be considered in patients with macroscopic hematuria, particularly in the kidney transplant recipients with idiopathic chronic renal disease. Diagnosis of secondary bladder amyloidosis may result in the early detection of underlying diseases, which may contribute to patient prognosis.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-016-2273-2.pdf
Ending Page	4
Page Count	4
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-016-2273-2
Journal	BMC Research Notes
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2016-10-19
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences Bladder amyloidosis Familial Mediterranean fever Macroscopic hematuria Renal transplantation Medicine/Public Health
Content Type	Text
Resource Type	Case study
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Title Secondary bladder amyloidosis with familial Mediterraneanfever in a living donor kidney transplant recipient : a case report

Familial Mediterranean Fever developing in a Japanese kidney transplant recipient.

Living kidney transplantation between brothers with unrecognized renal amyloidosis as the first manifestation of familial Mediterranean fever: a case report

Renal and suprarenal insufficiency secondary to familial Mediterranean fever associated with amyloidosis: a case report

Familial Mediterranean fever in which Crohn’s disease was suspected: a case report

Renal hypouricemia in a recipient of living-donor kidney transplantation: a case report and literature review.

Human parvovirus B19 infection in a renal transplant recipient: a case report

The frequency of familial mediterranean Fever related amyloidosis in renal waiting list for transplantation.

Helicobacter cinaedi bacteremia with cellulitis in a living-donor kidney transplant recipient identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a case report

Secondary bladder amyloidosis with familial Mediterranean fever in a living donor kidney transplant recipient: a case report

Similar Documents

Title Secondary bladder amyloidosis with familial Mediterraneanfever in a living donor kidney transplant recipient : a case report

Familial Mediterranean Fever developing in a Japanese kidney transplant recipient.

Living kidney transplantation between brothers with unrecognized renal amyloidosis as the first manifestation of familial Mediterranean fever: a case report

Renal and suprarenal insufficiency secondary to familial Mediterranean fever associated with amyloidosis: a case report

Familial Mediterranean fever in which Crohn’s disease was suspected: a case report

Renal hypouricemia in a recipient of living-donor kidney transplantation: a case report and literature review.

Human parvovirus B19 infection in a renal transplant recipient: a case report

The frequency of familial mediterranean Fever related amyloidosis in renal waiting list for transplantation.

Helicobacter cinaedi bacteremia with cellulitis in a living-donor kidney transplant recipient identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a case report

Secondary bladder amyloidosis with familial Mediterranean fever in a living donor kidney transplant recipient: a case report