NDLI: The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure

Content Provider	Springer Nature : BioMed Central
Author	Vasin, A. V. Petrova, A. V. Egorov, V. V. Plotnikova, M. A. Klotchenko, S. A. Karpenko, M. N. Kiselev, O. I.
Abstract	Background Influenza A virus (IAV) is a segmented negative-sense RNA virus that causes seasonal epidemics and periodic pandemics in humans. Two regions (nucleotide positions 82–148 and 497–564) in the positive-sense RNA of the NS segment fold into a multi-branch loop or hairpin structures. Results We studied 25,384 NS segment positive-sense RNA unique sequences of human and non-human IAVs in order to predict secondary RNA structures of the 82–148 and 497–564 regions using RNAfold software, and determined their host- and lineage-specific distributions. Hairpins prevailed in avian and avian-origin human IAVs, including H1N1pdm1918 and H5N1. In human and swine IAV hairpins distribution varied between evolutionary lineages. Conclusions These results suggest a possible functional role for these RNA secondary structures and the need for experimental evaluation of these structures in the influenza life cycle.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-016-2083-6.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-016-2083-6
Journal	BMC Research Notes
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2016-05-20
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences Influenza A virus RNA secondary structure RNA hairpin Pathogenicity NS gene Evolution Medicine/Public Health
Content Type	Text
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure

Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection

Influenza B virus has global ordered RNA structure in (+) and (−) strands but relatively less stable predicted RNA folding free energy than allowed by the encoded protein sequence

Influenza a virus coding regions exhibit host-specific global ordered rna structure (2012).

Construction of influenza virosome from influenza A H1N1 PR8

Identification of conserved RNA secondary structures at influenza B and C splice sites reveals similarities and differences between influenza A, B, and C

Functional evaluation for adequacy of MDCK-lineage cells in influenza research

Modeling influenza sequence evolution for vaccination

Conserved Secondary Structures in Aspergillus (2008)

The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure

Similar Documents

The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure

Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection

Influenza B virus has global ordered RNA structure in (+) and (−) strands but relatively less stable predicted RNA folding free energy than allowed by the encoded protein sequence

Influenza a virus coding regions exhibit host-specific global ordered rna structure (2012).

Construction of influenza virosome from influenza A H1N1 PR8

Identification of conserved RNA secondary structures at influenza B and C splice sites reveals similarities and differences between influenza A, B, and C

Functional evaluation for adequacy of MDCK-lineage cells in influenza research

Modeling influenza sequence evolution for vaccination

Conserved Secondary Structures in Aspergillus (2008)

The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure