NDLI: Use of propensity score methods to address adverse events associated with the storage time of blood in an obstetric population: a comparison of methods

Content Provider	Springer Nature : BioMed Central
Author	Patterson, Jillian A. Stuart, Elizabeth A. Ford, Jane B.
Abstract	Background A recent topic of interest in the blood transfusion literature is the existence of adverse effects of transfusing red cells towards the end of their storage life. This interest has been sparked by conflicting results in observational studies, however a number of methodological difficulties with these studies have been noted. One potential strategy to address these difficulties is the use of propensity scores, of which there are a number of possible methods. This study aims to compare the traditional methods for binary exposures with more recently developed generalised propensity score methods. Methods Data were obtained from probabilistically linked hospital, births and blood bank databases for all women giving birth from 23 weeks gestation in New South Wales, Australia, between July 2006 and December 2010 with complete information on the birth admission and blood issued. Analysis was restricted to women who received 1–4 units of red cells. Three different propensity score methods (for binary, ordinal and continuous exposures) were compared, using each of four different approaches to estimating the effect (matching, stratifying, weighting and adjusting by the propensity score). Each method was used to determine the effect of blood storage time on rates of severe morbidity and readmission or transfer. Results Data were available for 2990 deliveries to women receiving 1–4 units of red cells. The rate of severe maternal morbidity was 3.7 %, and of readmission or transfer was 14.4 %. There was no association between blood storage time and rates of severe morbidity or readmission irrespective of the approach used. There was no single optimal propensity score method; the approaches differed in their ease of implementation and interpretation. Conclusions Within an obstetric population, there was no evidence of an increase in adverse events following transfusion of older blood. Propensity score methods provide a useful tool for addressing the question of adverse events with increasing storage time of blood, as these methods avoid many of the pitfalls of previous studies. In particular, generalised propensity scores can be used in situations where the exposure is not binary.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-016-2169-1.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-016-2169-1
Journal	BMC Research Notes
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2016-07-26
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences Propensity score methods Blood transfusion Observational study Obstetrics Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

Adverse effects of small-volume red blood cell transfusions in the neonatal population

Rosiglitazone use and associated adverse event rates in Canada: an updated analysis

Rosiglitazone use and associated adverse event rates in Canada between 2004 and 2010

Predictors of response and anti-TNF drugs comparative efficacy

A comparison of three column agglutination tests for red blood cell alloantibody identification

Blood Transfusions and Adverse Events after Colorectal Surgery: A Propensity-Score-Matched Analysis of a Hen-Egg Issue.

Hospital variation in transfusion and infection after cardiac surgery: a cohort study

Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis

Use of propensity score methods to address adverse events associated with the storage time of blood in an obstetric population: a comparison of methods

Similar Documents

Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

Adverse effects of small-volume red blood cell transfusions in the neonatal population

Rosiglitazone use and associated adverse event rates in Canada: an updated analysis

Rosiglitazone use and associated adverse event rates in Canada between 2004 and 2010

Predictors of response and anti-TNF drugs comparative efficacy

A comparison of three column agglutination tests for red blood cell alloantibody identification

Blood Transfusions and Adverse Events after Colorectal Surgery: A Propensity-Score-Matched Analysis of a Hen-Egg Issue.

Hospital variation in transfusion and infection after cardiac surgery: a cohort study

Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis

Use of propensity score methods to address adverse events associated with the storage time of blood in an obstetric population: a comparison of methods