NDLI: Completion of nodal dissection in cutaneous melanoma with metastatic sentinel nodes: Prognostic impact in a population-based cohort study

Content Provider	Springer Nature : BioMed Central
Author	Buja, Alessandra Rugge, Massimo Trevisiol, Chiara Zanovello, Anna Mazza, Marcodomenico Dall’Olmo, Luigi Zorzi, Manuel Vecchiato, Antonella Del Fiore, Paolo Rossi, Carlo Riccardo Mocellin, Simone
Abstract	Background In primary cutaneous melanoma (CM) with metastatic sentinel lymph node(s) (SLNB), treatment strategies may include completing a regional lymph node dissection (CLND). The prognostic benefit of this therapeutic approach remains a topic of debate. This retrospective, population-based cohort study explores the prognostic impact of CLND in a real-world clinical setting. Methods This study analysed 280 incident cases of AJCC stage III CM with metastatic SLNB, as recorded by the Veneto population-based Regional Cancer Registry in 2015, 2017, and 2019. The overall survival and CM-specific survival rates were compared between patients who underwent CLND and those who did not. Kaplan-Meier analysis, Cox regression, and Fine-Gray models for competing risks tested the relationship between lymphadenectomy and overall and CM-specific survival. Results Among CM patients with metastatic SLNB, 199/280 (71.1%) proceeded with CLND. When compared to those who did not receive treatment, CLND did not demonstrate significant advantages in terms of overall survival and CM-specific survival rates. The cost analysis found no significant differences in treatment choice (estimated costs: €23,695.71 for the treated group and €25,003.55 for the untreated group [p = 0.69]). Conclusions The present real-world data support omitting CLND in stage III CM with histologically documented sentinel nodal metastasis.
Related Links	https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-025-03762-w.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14777819
DOI	10.1186/s12957-025-03762-w
Journal	World Journal of Surgical Oncology
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2025-03-29
Access Restriction	Open
Subject Keyword	Surgical Oncology Cutaneous melanoma Melanoma surgery Lymphadenectomy Survival Direct costs Cohort study Real-world data
Content Type	Text
Resource Type	Article
Subject	Oncology Surgery
Journal Impact Factor	2.5/2023
5-Year Journal Impact Factor	2.8/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Is Completion Lymphadenectomy After a Positive Sentinel Lymph Node Biopsy for Cutaneous Melanoma Always Necessary?

The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086)

Clinical Significance of Microscopic Melanoma Metastases in the Nonhottest Sentinel Lymph Nodes

Diagnostic biopsy of cutaneous melanoma, sentinel lymph node biopsy and indications for lymphadenectomy.

Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors

Impact of sentinel lymphadenectomy on survival in a murine model of melanoma

Lymph nodes and the melanoma surgeon: re-defining a long-term relationship.

Lymphedema After Sentinel Lymph Node Biopsy for Cutaneous Melanoma: A Report of 5 Cases

bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study

Completion of nodal dissection in cutaneous melanoma with metastatic sentinel nodes: Prognostic impact in a population-based cohort study

Similar Documents

Is Completion Lymphadenectomy After a Positive Sentinel Lymph Node Biopsy for Cutaneous Melanoma Always Necessary?

The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086)

Clinical Significance of Microscopic Melanoma Metastases in the Nonhottest Sentinel Lymph Nodes

Diagnostic biopsy of cutaneous melanoma, sentinel lymph node biopsy and indications for lymphadenectomy.

Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors

Impact of sentinel lymphadenectomy on survival in a murine model of melanoma

Lymph nodes and the melanoma surgeon: re-defining a long-term relationship.

Lymphedema After Sentinel Lymph Node Biopsy for Cutaneous Melanoma: A Report of 5 Cases

bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study

Completion of nodal dissection in cutaneous melanoma with metastatic sentinel nodes: Prognostic impact in a population-based cohort study