NDLI: Body composition analysis using CT at three aspects of the lumbar third vertebra and its impact on the diagnosis of sarcopenia

Content Provider	Springer Nature : BioMed Central
Author	Yang, Hui Gao, Zekan Shen, Qingzheng Zhi, Huaiqing Cai, Wentao Wang, Xiang Chen, Xiaodong Shen, Xian Zhang, Weiteng
Abstract	Purpose The European Working Group on Sarcopenia in Older People (EWGSOP) revised the consensus in 2018, including that using computed tomography (CT) imaging of the lumbar third vertebra (L3) for the evaluation of muscle mass. However, there is currently discrepancy and confusion in the application of specific cross-sectional and cutoff values for L3. This study aimed to standardize the diagnosis of low muscle mass using L3-CT. Materials and methods This study included patients who underwent radical gastrectomy for gastric cancer between July 2014 and February 2019. Sarcopenia factors were measured preoperatively. Patients were followed up to obtain actual clinical outcomes. We used the cutoff values obtained based on the inferior aspect of L3-CT images to diagnose sarcopenia in three aspects, respectively. Univariate and multivariate analyses were used to compare long-term and short-term postoperative prognostic differences. Results Sarcopenia was found to be an independent risk factor for postoperative complications and overall survival in patients with all three diagnoses of sarcopenia. According to the multivariate model for predicting postoperative complications, patients with inferior-L3 sarcopenia (n = 154,13.8%) had a greater odds ratio (OR) than patients with superior-L3 sarcopenia (n = 220,19.7%) or transverse-L3 sarcopenia (n = 194,17.4%) did (OR, inferior sarcopenia vs. superior sarcopenia, transverse sarcopenia, 2.030 vs. 1.608, 1.679). Furthermore, patients with inferior-L3 sarcopenia had the highest hazard ratio (HR) (HR, inferior sarcopenia vs. superior sarcopenia, transverse sarcopenia, 1.491 vs. 1.408, 1.376) in the multivariate model for predicting overall survival. Conclusion We recommend that when diagnosing low muscle mass using L3-CT, the intercepted cross section should be uniform and consistent with the aspect on which the cutoff value is based.
Related Links	https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-024-03634-9.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14777819
DOI	10.1186/s12957-024-03634-9
Journal	World Journal of Surgical Oncology
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2025-02-26
Access Restriction	Open
Subject Keyword	Surgical Oncology Sarcopenia Gastric cancer Muscle quantity Lumbar third vertebra Computed tomography
Content Type	Text
Resource Type	Article
Subject	Oncology Surgery
Journal Impact Factor	2.5/2023
5-Year Journal Impact Factor	2.8/2023

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